TAM Receptors Are Not Required for Zika Virus Infection in Mice

Andrew K. Hastings, Laura J. Yockey, Brett W. Jagger, Jesse Hwang, Ryuta Uraki, Hallie F. Gaitsch, Lindsay A. Parnell, Bin Cao, Indira U. Mysorekar, Carla V. Rothlin, Erol Fikrig, Michael S. Diamond, Akiko Iwasaki

Research output: Contribution to journalArticlepeer-review

100 Scopus citations


Tyro3, Axl, and Mertk (TAM) receptors are candidate entry receptors for infection with the Zika virus (ZIKV), an emerging flavivirus of global public health concern. To investigate the requirement of TAM receptors for ZIKV infection, we used several routes of viral inoculation and compared viral replication in wild-type versus Axl−/−, Mertk−/−, Axl−/−Mertk−/−, and Axl−/−Tyro3−/− mice in various organs. Pregnant and non-pregnant mice treated with interferon-α-receptor (IFNAR)-blocking (MAR1-5A3) antibody and infected subcutaneously with ZIKV showed no reliance on TAMs for infection. In the absence of IFNAR-blocking antibody, adult female mice challenged intravaginally with ZIKV showed no difference in mucosal viral titers. Similarly, in young mice that were infected with ZIKV intracranially or intraperitoneally, ZIKV replication occurred in the absence of TAM receptors, and no differences in cell tropism were observed. These findings indicate that, in mice, TAM receptors are not required for ZIKV entry and infection.

Original languageEnglish
Pages (from-to)558-568
Number of pages11
JournalCell Reports
Issue number3
StatePublished - Apr 18 2017


  • CNS
  • congenital infection
  • flavivirus
  • neurotropic virus
  • pregnancy
  • viral entry


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