T lymphocyte differentiation in the periphery

Kenneth M. Murphy

doi:10.1016/S0952-7915(98)80253-7

T lymphocyte differentiation in the periphery

Kenneth M. Murphy

Research output: Contribution to journal › Article › peer-review

86 Scopus citations

Abstract

The development of immune responses is significantly influenced by emerging patterns of cytokine expression in activated CD4⁺ T cells. Recent efforts have clarified both cellular and molecular mechanisms, and within the past year include significant observations on potential sources of IL-4 leading to Th2 development against certain pathogens, and insights into early responses and genetic susceptibility to experimental murine Leishmaniasis and transcriptional regulation of the IL-4 locus. Advances in Th1 development have included greater understanding of IL-12 receptors in Th1 development, data regarding IFN-γ gene expression and clarification of the action of the new cytokine IL-18.

Original language	English
Pages (from-to)	226-232
Number of pages	7
Journal	Current Opinion in Immunology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1016/S0952-7915(98)80253-7
State	Published - Apr 1998

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10.1016/S0952-7915(98)80253-7

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title = "T lymphocyte differentiation in the periphery",

abstract = "The development of immune responses is significantly influenced by emerging patterns of cytokine expression in activated CD4+ T cells. Recent efforts have clarified both cellular and molecular mechanisms, and within the past year include significant observations on potential sources of IL-4 leading to Th2 development against certain pathogens, and insights into early responses and genetic susceptibility to experimental murine Leishmaniasis and transcriptional regulation of the IL-4 locus. Advances in Th1 development have included greater understanding of IL-12 receptors in Th1 development, data regarding IFN-γ gene expression and clarification of the action of the new cytokine IL-18.",

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AB - The development of immune responses is significantly influenced by emerging patterns of cytokine expression in activated CD4+ T cells. Recent efforts have clarified both cellular and molecular mechanisms, and within the past year include significant observations on potential sources of IL-4 leading to Th2 development against certain pathogens, and insights into early responses and genetic susceptibility to experimental murine Leishmaniasis and transcriptional regulation of the IL-4 locus. Advances in Th1 development have included greater understanding of IL-12 receptors in Th1 development, data regarding IFN-γ gene expression and clarification of the action of the new cytokine IL-18.

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T lymphocyte differentiation in the periphery

Abstract

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