T helper cell subsets require the expression of distinct costimulatory signals by antigen-presenting cells

C. T. Weaver, C. M. Hawrylowicz, E. R. Unanue

Research output: Contribution to journalArticlepeer-review

212 Scopus citations

Abstract

We examined the ability of macrophages and B cells to function as antigen-presenting cells (APCs) for murine T(H)1 and T(H)2 cloned T helper cell lines. Antigen presented by concanavalin A-elicited peritoneal macrophages or resting splenic B cells stimulated antigen-dependent proliferation of both T helper subsets. Paraformaldehyde fixation of the APCs following different conditions of activation indicated differential requirements for costimulatory signals by T(H)1 and T(H)2 cells. T(H)2 proliferative responses were strictly dependent on APC expression of IL-1. T(H)1 proliferation was dependent on APC expression of a non-IL-1 costimulatory signal present on freshly isolated macrophages and on splenic B cells activated with anti-immunoglobulin plus interferon γ.

Original languageEnglish
Pages (from-to)8181-8185
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume85
Issue number21
DOIs
StatePublished - 1988

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