T cells mediate treatment of six-day-old cytokine-gene-transfected mouse mammary tumor

Yvedt L. Matory, David M. Dorfman, Man Chen, Lei Wu, Remco A. Spanjaard, Peter S. Goedegebuure, Timothy J. Eberlein

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

We have previously shown that immunologically different mouse mammary cancer cell lines induce antitumor responses after IL2 or IL4 gene transfection. We now report the ability of cytokine-transfected tumors to induce eradication of established wild-type tumor. Animals with 6-day-old tumor treated with IL2-transfected cells also had significantly smaller tumors 2.8 and 1.7 cm2 (EMT6 and 410.4). Findings were similar for IL4-transfected cells. Tumor infiltrating lymphocytes or cells from draining lymph nodes demonstrated tumor-specific in vitro cytotoxicity. Immunohistochemical studies revealed T cell infiltrates in transfected tumors.

Original languageEnglish
Pages (from-to)3-11
Number of pages9
JournalPathobiology
Volume67
Issue number1
DOIs
StatePublished - Jan 1999

Keywords

  • Cytokine gene transfection mammary cancer

Fingerprint

Dive into the research topics of 'T cells mediate treatment of six-day-old cytokine-gene-transfected mouse mammary tumor'. Together they form a unique fingerprint.

Cite this