T cells mediate treatment of six-day-old cytokine-gene-transfected mouse mammary tumor

Yvedt L. Matory; David M. Dorfman; Man Chen; Lei Wu; Remco A. Spanjaard; Peter S. Goedegebuure; Timothy J. Eberlein

doi:10.1159/000028044

T cells mediate treatment of six-day-old cytokine-gene-transfected mouse mammary tumor

Yvedt L. Matory, David M. Dorfman, Man Chen, Lei Wu, Remco A. Spanjaard, Peter S. Goedegebuure, Timothy J. Eberlein

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

We have previously shown that immunologically different mouse mammary cancer cell lines induce antitumor responses after IL2 or IL4 gene transfection. We now report the ability of cytokine-transfected tumors to induce eradication of established wild-type tumor. Animals with 6-day-old tumor treated with IL2-transfected cells also had significantly smaller tumors 2.8 and 1.7 cm² (EMT6 and 410.4). Findings were similar for IL4-transfected cells. Tumor infiltrating lymphocytes or cells from draining lymph nodes demonstrated tumor-specific in vitro cytotoxicity. Immunohistochemical studies revealed T cell infiltrates in transfected tumors.

Original language	English
Pages (from-to)	3-11
Number of pages	9
Journal	Pathobiology
Volume	67
Issue number	1
DOIs	https://doi.org/10.1159/000028044
State	Published - Jan 1999

Keywords

Cytokine gene transfection mammary cancer

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title = "T cells mediate treatment of six-day-old cytokine-gene-transfected mouse mammary tumor",

abstract = "We have previously shown that immunologically different mouse mammary cancer cell lines induce antitumor responses after IL2 or IL4 gene transfection. We now report the ability of cytokine-transfected tumors to induce eradication of established wild-type tumor. Animals with 6-day-old tumor treated with IL2-transfected cells also had significantly smaller tumors 2.8 and 1.7 cm2 (EMT6 and 410.4). Findings were similar for IL4-transfected cells. Tumor infiltrating lymphocytes or cells from draining lymph nodes demonstrated tumor-specific in vitro cytotoxicity. Immunohistochemical studies revealed T cell infiltrates in transfected tumors.",

keywords = "Cytokine gene transfection mammary cancer",

author = "Matory, {Yvedt L.} and Dorfman, {David M.} and Man Chen and Lei Wu and Spanjaard, {Remco A.} and Goedegebuure, {Peter S.} and Eberlein, {Timothy J.}",

year = "1999",

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doi = "10.1159/000028044",

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T1 - T cells mediate treatment of six-day-old cytokine-gene-transfected mouse mammary tumor

AU - Matory, Yvedt L.

AU - Dorfman, David M.

AU - Chen, Man

AU - Wu, Lei

AU - Spanjaard, Remco A.

AU - Goedegebuure, Peter S.

AU - Eberlein, Timothy J.

PY - 1999/1

Y1 - 1999/1

N2 - We have previously shown that immunologically different mouse mammary cancer cell lines induce antitumor responses after IL2 or IL4 gene transfection. We now report the ability of cytokine-transfected tumors to induce eradication of established wild-type tumor. Animals with 6-day-old tumor treated with IL2-transfected cells also had significantly smaller tumors 2.8 and 1.7 cm2 (EMT6 and 410.4). Findings were similar for IL4-transfected cells. Tumor infiltrating lymphocytes or cells from draining lymph nodes demonstrated tumor-specific in vitro cytotoxicity. Immunohistochemical studies revealed T cell infiltrates in transfected tumors.

AB - We have previously shown that immunologically different mouse mammary cancer cell lines induce antitumor responses after IL2 or IL4 gene transfection. We now report the ability of cytokine-transfected tumors to induce eradication of established wild-type tumor. Animals with 6-day-old tumor treated with IL2-transfected cells also had significantly smaller tumors 2.8 and 1.7 cm2 (EMT6 and 410.4). Findings were similar for IL4-transfected cells. Tumor infiltrating lymphocytes or cells from draining lymph nodes demonstrated tumor-specific in vitro cytotoxicity. Immunohistochemical studies revealed T cell infiltrates in transfected tumors.

KW - Cytokine gene transfection mammary cancer

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AN - SCOPUS:0032936445

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VL - 67

SP - 3

EP - 11

JO - Pathobiology

JF - Pathobiology

IS - 1

ER -

T cells mediate treatment of six-day-old cytokine-gene-transfected mouse mammary tumor

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