Abstract
We have previously shown that immunologically different mouse mammary cancer cell lines induce antitumor responses after IL2 or IL4 gene transfection. We now report the ability of cytokine-transfected tumors to induce eradication of established wild-type tumor. Animals with 6-day-old tumor treated with IL2-transfected cells also had significantly smaller tumors 2.8 and 1.7 cm2 (EMT6 and 410.4). Findings were similar for IL4-transfected cells. Tumor infiltrating lymphocytes or cells from draining lymph nodes demonstrated tumor-specific in vitro cytotoxicity. Immunohistochemical studies revealed T cell infiltrates in transfected tumors.
Original language | English |
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Pages (from-to) | 3-11 |
Number of pages | 9 |
Journal | Pathobiology |
Volume | 67 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1999 |
Keywords
- Cytokine gene transfection mammary cancer