T cells and intestinal commensal bacteria-ignorance, rejection, and acceptance

Jiani N. Chai, You W. Zhou, Chyi Song Hsieh

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Trillions of commensal bacteria cohabit our bodies to mutual benefit. In the past several years, it has become clear that the adaptive immune system is not ignorant of intestinal commensal bacteria, but is constantly interacting with them. For T cells, the response to commensal bacteria does not appear uniform, as certain commensal bacterial species appear to trigger effector T cells to reject and control them, whereas other species elicit Foxp3+ regulatory T (Treg) cells to accept and be tolerant of them. Here, we review our current knowledge of T cell differentiation in response to commensal bacteria, and how this process leads to immune homeostasis in the intestine.

Original languageEnglish
Pages (from-to)4167-4175
Number of pages9
JournalFEBS Letters
Volume588
Issue number22
DOIs
StatePublished - Nov 17 2014

Keywords

  • Commensal
  • Effector cell
  • IgA
  • Inflammatory bowel disease
  • Intestine
  • Mucosa
  • T cell
  • Tolerance
  • Treg

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