T-cell prolymphocytic leukemia: Review of an entity and its differential diagnostic considerations

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Abstract

T-cell prolymphocytic leukemia (T-PLL) is a rare T-cell leukemia characterized in many patients by marked peripheral lymphocytosis, prominent splenomegaly, and skin lesions. The differential diagnosis is broad and includes other T-cell disorders presenting with similar clinical findings. This review addresses (a) the natural history, demographics, and genetic features of T-PLL; (b) clinical and pathologic differential diagnostic considerations; and (c) recent developments in the T-PLL literature relevant to laboratory professionals.

Original languageEnglish
Pages (from-to)90-98
Number of pages9
JournalInternational Journal of Laboratory Hematology
Volume42
Issue numberS1
DOIs
StatePublished - Jun 1 2020

Keywords

  • T-cells
  • leukemia
  • morphology

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