T cell inducing determinants contain a hierarchy of residues contacting the T cell receptor

Brian D. Evavold, Scott G. Williams, Jane S. Chen, Paul M. Allen

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

T cells through their antigen specific T cell receptor recognize a bi-molecular ligand composed of an antigenic peptide bound to a MHC molecule. Several T cell inducing determinants have been extensively characterized by single amino acid substitutions. In this review, we have summarized our characterization of four immunodominant determinants. Each of these determinants possessed a single amino acid residue which was absolutely critical for the recognition by T cells. From these data we propose a hypothesis that there is a hierarchy in the T cell contact residues of a determinant, composed of a single primary residue, and a few secondary residues.

Original languageEnglish
Pages (from-to)225-229
Number of pages5
JournalSeminars in immunology
Volume3
Issue number4
StatePublished - Dec 1 1991

Keywords

  • Antigen
  • Immunodominant determinants
  • MHC
  • T cell

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