T-cell deplete versus T-cell replete haploidentical hematopoietic stem cell transplantation for sickle cell disease: where are we?

Dilan A. Patel, Adeseye M. Akinsete, James A. Connelly, Adetola A. Kassim

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Introduction: Severe sickle cell disease is associated with progressive end-organ damage and early mortality in adults. While allogeneic hematopoietic cell transplant from a matched related donor is curative, the vast majority of patients do not have a compatible sibling. Accordingly, platforms using haploidentical donors have been developed, which provide near-universal availability. Areas covered: This review focuses on the two commonly used approaches for haploidentical hematopoietic transplants, namely T-cell deplete and T-cell replete, each of which is associated with unique benefits and drawbacks. The purpose of this paper is to facilitate individualized decision-making for patients and providers by reviewing the pros- and cons of these differing approaches. Expert opinion: Individuals with sickle cell disease eligible for a hematopoietic cell transplant can be considered based on recent results. Comparable outcomes are seen with T-cell deplete and T-cell replete approaches. The choice depends largely on institutional preference.

Original languageEnglish
Pages (from-to)733-752
Number of pages20
JournalExpert Review of Hematology
Volume12
Issue number9
DOIs
StatePublished - 2019

Keywords

  • graft-versus-host disease
  • Haploidentical transplant
  • sickle cell disease
  • T-cell deplete
  • T-cell replete
  • viruses

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