TY - JOUR
T1 - T cell control of inflammaging
AU - Shchukina, Irina
AU - Bohacova, Pavla
AU - Artyomov, Maxim N.
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/11
Y1 - 2023/11
N2 - T cells are a critical component of the immune system, found in abundance in blood, secondary lymphoid organs, and peripheral tissues. As individuals age, T cells are particularly susceptible to changes, making them one of the most affected immune subsets. These changes can have significant implications for age-related dysregulations, including the development of low-grade inflammation – a hallmark of aging known as inflammaging. In this review, we first present age-related changes in the functionality of the T cell compartment, including dysregulation of cytokine and chemokine production and cytotoxicity. Next, we discuss how these changes can contribute to the development and maintenance of inflammaging. Furthermore, we will summarize the mechanisms through which age-related changes in T cells may drive abnormal physiological outcomes.
AB - T cells are a critical component of the immune system, found in abundance in blood, secondary lymphoid organs, and peripheral tissues. As individuals age, T cells are particularly susceptible to changes, making them one of the most affected immune subsets. These changes can have significant implications for age-related dysregulations, including the development of low-grade inflammation – a hallmark of aging known as inflammaging. In this review, we first present age-related changes in the functionality of the T cell compartment, including dysregulation of cytokine and chemokine production and cytotoxicity. Next, we discuss how these changes can contribute to the development and maintenance of inflammaging. Furthermore, we will summarize the mechanisms through which age-related changes in T cells may drive abnormal physiological outcomes.
UR - http://www.scopus.com/inward/record.url?scp=85168833072&partnerID=8YFLogxK
U2 - 10.1016/j.smim.2023.101818
DO - 10.1016/j.smim.2023.101818
M3 - Review article
C2 - 37611324
AN - SCOPUS:85168833072
SN - 1044-5323
VL - 70
JO - Seminars in immunology
JF - Seminars in immunology
M1 - 101818
ER -