Systemic responses during local viral infections: Type I IFNs sound the alarm

Carolina B. López, Tamar Hermesh

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations

Abstract

Type I IFNs are well known for their role in controlling virus replication and spread. Type I IFNs produced by the infected tissue also signal beyond the boundaries of the infection to regulate different elements of the anti-viral immune response. Recent reports show that type I IFNs directly condition naive monocytes residing in the distal bone marrow (BM) and induce the expression of effector molecules in memory T cells, before their recruitment to the infected site. In addition, hematopoietic stem cells (HSCs) were shown to enter the cell cycle in response to systemically distributed type I IFNs. These discoveries expand our understanding of the pleiotropic effects of type I IFNs during infection and highlight the critical role of systemic signals in the development of an effective response to a localized viral infection.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalCurrent Opinion in Immunology
Volume23
Issue number4
DOIs
StatePublished - Aug 2011

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