@article{90bca1e8bc9c456ba135e086faf9101f,
title = "Systemic regulation of mammalian ageing and longevity by brain sirtuins",
abstract = "Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hypothalamus, in governing multiple physiological functions. These data provide strong evidence that brain sirtuins regulate mammalian ageing and longevity at the organismal level.",
author = "Akiko Satoh and Imai, \{Shin Ichiro\}",
note = "Funding Information: We apologize to those whose work is not cited due to space limitations. We thank Imai lab members, Cynthia S. Brace in particular, for stimulating discussions and critical reading of the manuscript. This work was supported by grants from the National Institute on Aging (AG024150, AG037457) and the Ellison Medical Foundation to S.I., and the JSPS Postdoctoral Fellowship for Research Abroad to A.S.",
year = "2014",
month = jun,
day = "26",
doi = "10.1038/ncomms5211",
language = "English",
volume = "5",
journal = "Nature communications",
issn = "2041-1723",
}