Systemic regulation of mammalian ageing and longevity by brain sirtuins

Akiko Satoh, Shin Ichiro Imai

Research output: Contribution to journalReview articlepeer-review

44 Scopus citations


Sirtuins regulate numerous important biological processes in mammals, including various age-associated pathophysiologies. However, whether sirtuins are critical to control ageing and longevity in mammals has been controversial. Recent studies have demonstrated critical roles of sirtuins in the brain, especially the hypothalamus, in governing multiple physiological functions. These data provide strong evidence that brain sirtuins regulate mammalian ageing and longevity at the organismal level.

Original languageEnglish
Article number4211
JournalNature communications
StatePublished - Jun 26 2014


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