Systemic mastocytosis with renal light chain amyloidosis: associated non-mast cell disorder or concurrent disease

Moussab Damlaj, Hanadi Ashi, Fouad Boulos, Hala Kfoury, Zaher Chakhachiro

Research output: Contribution to journalArticlepeer-review

Abstract

Systemic mastocytosis with an associated hematological neoplasm (SM-AHN) is a rare diagnosis commonly associated with myeloid disorders. Herein, we describe the case of a 53-year-old female diagnosed with systemic mastocytosis (SM) in conjunction with renal light chain amyloidosis (AL) and smoldering myeloma. Although cytokines such as IL-6 may play a role in the proliferation of plasma cells, delays in the diagnosis of SM and paucity of relevant studies cast uncertainty on whether the associated disease is secondary to the mast cells or etiologically independent. To our knowledge, this is the first case of confirmed renal AL disease in conjunction with SM. We review and summarize the available literature describing SM in association with plasma cell disorders.

Original languageEnglish
Pages (from-to)157-162
Number of pages6
JournalJournal of Hematopathology
Volume12
Issue number3
DOIs
StatePublished - Sep 1 2019

Keywords

  • Amyloidosis
  • Plasma cell disorder
  • Systemic mastocytosis

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