TY - JOUR
T1 - Systemic Capillary Leak Syndrome Secondary to Coronavirus Disease 2019
AU - Case, Robert
AU - Ramaniuk, Aliaksandr
AU - Martin, Pamela
AU - Simpson, Paul J.
AU - Harden, Christopher
AU - Ataya, Ali
N1 - Publisher Copyright:
© 2020 American College of Chest Physicians
PY - 2020/12
Y1 - 2020/12
N2 - Systemic capillary leak syndrome is a rare disorder characterized by dysfunctional inflammatory response, endothelial dysfunction, and extravasation of fluid from the vascular space to the interstitial space leading to shock, hemoconcentration, hypoalbuminemia, and subsequent organ failure. The condition may be idiopathic or secondary to an underlying cause, which can include viral infections. Here we describe a patient with acute coronavirus disease 2019 (COVID-19) infection who presented with hemoconcentration, shock, and hypoalbuminemia. The patient subsequently developed rhabdomyolysis and compartment syndrome of all four extremities, requiring fasciotomies. This is the first reported case of systemic capillary leak syndrome associated with COVID-19 infection. This case adds to the evolving spectrum of inflammatory effects associated with this viral infection.
AB - Systemic capillary leak syndrome is a rare disorder characterized by dysfunctional inflammatory response, endothelial dysfunction, and extravasation of fluid from the vascular space to the interstitial space leading to shock, hemoconcentration, hypoalbuminemia, and subsequent organ failure. The condition may be idiopathic or secondary to an underlying cause, which can include viral infections. Here we describe a patient with acute coronavirus disease 2019 (COVID-19) infection who presented with hemoconcentration, shock, and hypoalbuminemia. The patient subsequently developed rhabdomyolysis and compartment syndrome of all four extremities, requiring fasciotomies. This is the first reported case of systemic capillary leak syndrome associated with COVID-19 infection. This case adds to the evolving spectrum of inflammatory effects associated with this viral infection.
KW - COVID-19
KW - capillary leak
KW - shock
KW - systemic capillary leak syndrome
UR - http://www.scopus.com/inward/record.url?scp=85094606271&partnerID=8YFLogxK
U2 - 10.1016/j.chest.2020.06.049
DO - 10.1016/j.chest.2020.06.049
M3 - Article
C2 - 32622823
AN - SCOPUS:85094606271
SN - 0012-3692
VL - 158
SP - e267-e268
JO - CHEST
JF - CHEST
IS - 6
ER -