Systematic Review and Meta-analysis of en Bloc Vertebrectomy Compared with Intralesional Resection for Giant Cell Tumors of the Mobile Spine

Panya Luksanapruksa, Jacob M. Buchowski, Weerasak Singhatanadgige, David B. Bumpass

Research output: Contribution to journalReview articlepeer-review

7 Scopus citations

Abstract

Study Design Systematic review and meta-analysis. Objective To compare the recurrence and perioperative complication rate of en bloc vertebrectomy (EV) and intralesional resection (IR) in the giant cell tumor of the mobile spine (SGCT). Methods We systematically searched publications in the PubMed and Embase databases for reports of SGCTs, excluding the sacrum. Two reviewers independently assessed all publications. A meta-analysis was performed using local recurrence and postoperative complications as the primary outcomes of interest. Results There were four articles reporting recurrence and two articles reporting postoperative complications. All included articles were case series. In all, 91 patients were included; 49 were treated with IR and 42 were treated with EV. Local recurrence rates were 36.7 and 9.5% in the IR and EV groups, respectively. Rates of postoperative complications were 36.4% with IR and 11.1% with EV. Overall, patients treated with EV not only had a lower recurrence rate (relative risk [RR] 0.22; 95% confidence interval [CI] 0.09 to 0.52) but also had a lower postoperative complication rate (RR 0.34; 95% CI 0.07 to 1.52) compared with IR. Conclusions Based on the limited data obtained from systematic review, SGCT patients treated with EV had a lower recurrence rate and fewer postoperative complications than those treated with IR.

Original languageEnglish
Pages (from-to)798-803
Number of pages6
JournalGlobal Spine Journal
Volume6
Issue number8
DOIs
StatePublished - Dec 1 2016

Keywords

  • en bloc vertebrectomy
  • giant cell tumor
  • intralesional resection
  • meta-analysis
  • mobile spine
  • postoperative complications
  • recurrence

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