Systematic Review and Meta-analysis for Surgery Versus Stereotactic Radiosurgery for Jugular Paragangliomas

James C. Campbell, Jessica W. Lee, Leila Ledbetter, Cameron C. Wick, Kristal M. Riska, Calhoun D. Cunningham, Alessandra C. Russomando, Tracy Truong, Hwanhee Hong, Maragatha Kuchibhatla, David M. Kaylie

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Objective Comprehensively analyze tumor control and treatment complications for jugular paraganglioma patients undergoing surgery versus stereotactic radiosurgery (SRS). Databases Reviewed EMBASE, Medline, and Scopus. Methods The databases were searched for English and Spanish articles from January 1, 1995, to January, 1, 2019, for studies reporting tumor control and treatment side effects regarding patients with jugular paraganglioma treated with surgery or SRS. Main outcome measures included short-term and long-term tumor recurrence, as well as postintervention complications. Results We identified 10,952 original abstracts, 705 eligible studies, and 107 studies for final data extraction. There were 3,498 patients - 2,215 surgical patients and 1,283 SRS patients. Bayesian meta-analysis was applied to the extracted data, with tau measurements for study heterogeneity. SRS tumors were larger (3.9 cm3 versus 8.1 cm3). Meta-analysis results demonstrated low rates of long-term recurrence for both modalities (surgery, 15%; SRS, 7%), with SRS demonstrating lower rates of postintervention cerebrospinal fluid leak, dysphagia, and cranial nerve Vll, lX, X, Xl, or Xll palsies. Conclusions This study demonstrates excellent control of jugular paragangiomas with both surgery and SRS, with higher rates of lower cranial neuropathies, dysphagia, and cerebrospinal fluid leaks among surgical patients.

Original languageEnglish
Pages (from-to)195-200
Number of pages6
JournalOtology and Neurotology
Volume44
Issue number3
DOIs
StatePublished - Mar 1 2023

Keywords

  • Glomus jugulare
  • Jugular paraganglioma
  • Meta-analysis
  • Skull base surgery
  • Stereotactic radiosurgery
  • Systematic review

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