@article{025b99337b15476dba376494aeb66789,
title = "Systematic biological prioritization after a genome-wide association study: An application to nicotine dependence",
abstract = "Motivation: A challenging problem after a genome-wide association study (GWAS) is to balance the statistical evidence of genotype - phenotype correlation with a priori evidence of biological relevance. Results: We introduce a method for systematically prioritizing single nucleotide polymorphisms (SNPs) for further study after a GWAS. The method combines evidence across multiple domains including statistical evidence of genotype - phenotype correlation, known pathways in the pathologic development of disease, SNP/gene functional properties, comparative genomics, prior evidence of genetic linkage, and linkage disequilibrium. We apply this method to a GWAS of nicotine dependence, and use simulated data to test it on several commercial SNP microarrays.",
author = "Saccone, {Scott F.} and Saccone, {Nancy L.} and Swan, {Gary E.} and Madden, {Pamela A.F.} and Goate, {Alison M.} and Rice, {John P.} and Bierut, {Laura J.}",
note = "Funding Information: Funding: This work was supported by American Cancer Society (IRG5801050), the National Cancer Institute (P01CA89392), the National Institute on Drug Abuse (R01DA019963, R56DA12854, K02DA021237, K01DA015129 and N01DA07079), the National Human Genome Research Institute (U01HG004422), the National Institute of Alcohol Abuse and Alcoholism (U10AA008401), and the National Institute of Mental Health (U24MH068457). The NicSNP project is a collaborative research group and part of the NIDA Genetics Consortium, and NicSNP genotyping was performed by Perlegen Sciences under NIDA Contract HHSN271200477471C. Phenotypic and genotypic data for the NicSNP project are stored in the NIDA Center for Genetic Studies (NCGS) at http://zork.wustl.edu/.",
year = "2008",
month = aug,
doi = "10.1093/bioinformatics/btn315",
language = "English",
volume = "24",
pages = "1805--1811",
journal = "Bioinformatics",
issn = "1367-4803",
number = "16",
}