Systematic bias between blood pH instruments

J. H. Ladenson, C. H. Smith, D. N. Dietzler, J. E. Davis

Research output: Contribution to journalArticle

3 Scopus citations


Measurement of tris (hydroxymethyl) aminomethane buffers and blood samples was used to compare the following commercial pH instruments: Corning Models 160 and 165, Instrumentation Laboratory, Inc. Model 313, and Radiometer Models E5021 and BMS 3MK2. These comparisons uncovered a systematic bias of 0.02 pH units in Instrumentation Laboratory, Inc. electrodes manufactured before April 1973. Other factors found to affect analytical results were the temperature of the saturated KCl salt bridge and reference electrode, the design of the temperature control system, and the buffer used to standardize the instruments.

Original languageEnglish
Pages (from-to)1341-1343
Number of pages3
JournalClinical chemistry
Issue number10
StatePublished - Jan 1 1974

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