TY - JOUR
T1 - Synthetic Ways to Tris(nucleobase) Complexes Derived from cis-Diammineplatinum(II) and a Platinum(II) Complex Containing Four Different Ligands, Three of Which Are Nucleobases
AU - Hegmans, Alexander
AU - Sabat, Michal
AU - Baxter, Ivan
AU - Freisinger, Eva
AU - Lippert, Bernhard
PY - 1998
Y1 - 1998
N2 - Reactions of cis-[PtCl(L-N7)(NH3)2]CI (L = 9-ethylguanine, 9-EtGH, or 9-methyladenine, 9-MeA) with excess KI leads in slightly acidic solution to trans-PtI2(L)(NH3). Partial or complete substitution of the iodo ligands by aqua, chloro, or nucieobase ligands can be achieved and gives a series of neutral or cationic complexes. Among others, tris(nucleobase) complexes containing three different nucleobases (9-EtGH, 9-MeA, and 1-methylcytosine, 1-MeC), [Pt(1-MeC)(9-EtGH)(9-MeA)(NH3)]2+ with SP-4-3 and SP-4-4 configuration numbers have been prepared and the deprotonated form SP-4-4-[Pt(1-MeC-N3)(9-EtG-N7)(9-MeA-N7)(NH3)]NO 3·2H2O (7b) has been X-ray structurally characterized: monoclinic system, space group C2/c, a = 23.817(5) Å, b = 10.992(2) Å, c = 21.647-(4) Å, β = 112.07(3)°, V = 5251.9 Å3 Z = 8. Moreover, the X-ray crystal structure analyses of trans-PtCl2-(9-EtGH-N7)(NH3)·0.5H2O (4) and trans-[Pt(1-MeC-N3)2(9-EtG-N7)(NH3)]NO 3·3H2O (6b) are reported. 4: triclinic system, space group P1̄ (No. 2), a = 11.557(3) Å, b = 12.742(2) Å, c = 8.880(2) Å, α = 96.95(1)°, β = 94.91(2)°, γ = 88.32(2)°, V = 1293.1(5) Å3, Z = 4. 6b: triclinic system, space group P1̄ (No. 2), a = 10.957(2) Å, b= 11.022(2) Å, c = 12.916(2) Å, α = 81.18(3)°, β = 89.93(3)°, γ = 64.22(3)°, V = 1384.2(5) Å3, Z = 2. Relative orientations of the nucleobases in these compounds appear to be dictated by intranucleobase H bond formation.
AB - Reactions of cis-[PtCl(L-N7)(NH3)2]CI (L = 9-ethylguanine, 9-EtGH, or 9-methyladenine, 9-MeA) with excess KI leads in slightly acidic solution to trans-PtI2(L)(NH3). Partial or complete substitution of the iodo ligands by aqua, chloro, or nucieobase ligands can be achieved and gives a series of neutral or cationic complexes. Among others, tris(nucleobase) complexes containing three different nucleobases (9-EtGH, 9-MeA, and 1-methylcytosine, 1-MeC), [Pt(1-MeC)(9-EtGH)(9-MeA)(NH3)]2+ with SP-4-3 and SP-4-4 configuration numbers have been prepared and the deprotonated form SP-4-4-[Pt(1-MeC-N3)(9-EtG-N7)(9-MeA-N7)(NH3)]NO 3·2H2O (7b) has been X-ray structurally characterized: monoclinic system, space group C2/c, a = 23.817(5) Å, b = 10.992(2) Å, c = 21.647-(4) Å, β = 112.07(3)°, V = 5251.9 Å3 Z = 8. Moreover, the X-ray crystal structure analyses of trans-PtCl2-(9-EtGH-N7)(NH3)·0.5H2O (4) and trans-[Pt(1-MeC-N3)2(9-EtG-N7)(NH3)]NO 3·3H2O (6b) are reported. 4: triclinic system, space group P1̄ (No. 2), a = 11.557(3) Å, b = 12.742(2) Å, c = 8.880(2) Å, α = 96.95(1)°, β = 94.91(2)°, γ = 88.32(2)°, V = 1293.1(5) Å3, Z = 4. 6b: triclinic system, space group P1̄ (No. 2), a = 10.957(2) Å, b= 11.022(2) Å, c = 12.916(2) Å, α = 81.18(3)°, β = 89.93(3)°, γ = 64.22(3)°, V = 1384.2(5) Å3, Z = 2. Relative orientations of the nucleobases in these compounds appear to be dictated by intranucleobase H bond formation.
UR - http://www.scopus.com/inward/record.url?scp=0000739490&partnerID=8YFLogxK
U2 - 10.1021/ic9802193
DO - 10.1021/ic9802193
M3 - Article
AN - SCOPUS:0000739490
SN - 0020-1669
VL - 37
SP - 4921
EP - 4928
JO - Inorganic Chemistry
JF - Inorganic Chemistry
IS - 19
ER -