Synthetic polymer nanoparticles conjugated with FimH A from E. coli pili to emulate the bacterial mode of epithelial internalization

Lily Yun Lin; Kristin M. Tiemann; Yali Li; Jerome S. Pinkner; Jennifer N. Walker; Scott J. Hultgren; David A. Hunstad; Karen L. Wooley

doi:10.1021/ja2091917

Synthetic polymer nanoparticles conjugated with FimH _A from E. coli pili to emulate the bacterial mode of epithelial internalization

Lily Yun Lin
, Kristin M. Tiemann
, Yali Li
, Jerome S. Pinkner
, Jennifer N. Walker
, Scott J. Hultgren
, David A. Hunstad
, Karen L. Wooley

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH _A through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

Original language	English
Pages (from-to)	3938-3941
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	134
Issue number	9
DOIs	https://doi.org/10.1021/ja2091917
State	Published - Mar 7 2012

Access to Document

10.1021/ja2091917

Cite this

@article{f753d95f556f43a3b6dd39ad56e57201,

title = "Synthetic polymer nanoparticles conjugated with FimH A from E. coli pili to emulate the bacterial mode of epithelial internalization",

abstract = "Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH A through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.",

author = "Lin, \{Lily Yun\} and Tiemann, \{Kristin M.\} and Yali Li and Pinkner, \{Jerome S.\} and Walker, \{Jennifer N.\} and Hultgren, \{Scott J.\} and Hunstad, \{David A.\} and Wooley, \{Karen L.\}",

year = "2012",

month = mar,

day = "7",

doi = "10.1021/ja2091917",

language = "English",

volume = "134",

pages = "3938--3941",

journal = "Journal of the American Chemical Society",

issn = "0002-7863",

number = "9",

}

TY - JOUR

T1 - Synthetic polymer nanoparticles conjugated with FimH A from E. coli pili to emulate the bacterial mode of epithelial internalization

AU - Lin, Lily Yun

AU - Tiemann, Kristin M.

AU - Li, Yali

AU - Pinkner, Jerome S.

AU - Walker, Jennifer N.

AU - Hultgren, Scott J.

AU - Hunstad, David A.

AU - Wooley, Karen L.

PY - 2012/3/7

Y1 - 2012/3/7

N2 - Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH A through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

AB - Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH A through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

UR - https://www.scopus.com/pages/publications/84863233142

U2 - 10.1021/ja2091917

DO - 10.1021/ja2091917

M3 - Article

C2 - 22360307

AN - SCOPUS:84863233142

SN - 0002-7863

VL - 134

SP - 3938

EP - 3941

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 9

ER -

Synthetic polymer nanoparticles conjugated with FimH _A from E. coli pili to emulate the bacterial mode of epithelial internalization

Abstract

Access to Document

Other files and links

Fingerprint

Cite this