Synthetic polymer nanoparticles conjugated with FimH A from E. coli pili to emulate the bacterial mode of epithelial internalization

Lily Yun Lin, Kristin M. Tiemann, Yali Li, Jerome S. Pinkner, Jennifer N. Walker, Scott J. Hultgren, David A. Hunstad, Karen L. Wooley

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Amphiphilic block copolymer nanoparticles are conjugated with uropathogenic Escherichia coli type 1 pilus adhesin FimH A through amidation chemistry to enable bladder epithelial cell binding and internalization of the nanoparticles in vitro.

Original languageEnglish
Pages (from-to)3938-3941
Number of pages4
JournalJournal of the American Chemical Society
Volume134
Issue number9
DOIs
StatePublished - Mar 7 2012

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