Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([3H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site

A. Thurkauf, B. de Costa, P. Berger, S. Paul, K. C. Rice

Research output: Contribution to journalArticlepeer-review

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Abstract

A tritiated photoaffinity ligand for the dopamine reuptake transporter protein, 1‐[2‐(diphenylmethoxy) ethyl]‐4‐[3‐(3‐azidophenyl)‐2,3‐ditritiopropyl]piperazine, of specific activity 41.8 Ci/mmol, was prepared in six steps starting from 1‐[2‐(diphenylmethoxy)ethyl] piperazine.

Original languageEnglish
Pages (from-to)125-129
Number of pages5
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume29
Issue number2
DOIs
StatePublished - Feb 1991

Keywords

  • 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine
  • 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐phenylpropyl]piperazine
  • Cocaine
  • GBR‐12935
  • dopamine reuptake
  • tritium

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