Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([3H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site

A. Thurkauf; B. de Costa; P. Berger; S. Paul; K. C. Rice

doi:10.1002/jlcr.2580290202

Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([³H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site

A. Thurkauf, B. de Costa, P. Berger, S. Paul, K. C. Rice

Washington University School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A tritiated photoaffinity ligand for the dopamine reuptake transporter protein, 1‐[2‐(diphenylmethoxy) ethyl]‐4‐[3‐(3‐azidophenyl)‐2,3‐ditritiopropyl]piperazine, of specific activity 41.8 Ci/mmol, was prepared in six steps starting from 1‐[2‐(diphenylmethoxy)ethyl] piperazine.

Original language	English
Pages (from-to)	125-129
Number of pages	5
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	29
Issue number	2
DOIs	https://doi.org/10.1002/jlcr.2580290202
State	Published - Feb 1991

Keywords

1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine
1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐phenylpropyl]piperazine
Cocaine
GBR‐12935
dopamine reuptake
tritium

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10.1002/jlcr.2580290202

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Thurkauf, A., de Costa, B., Berger, P., Paul, S., & Rice, K. C. (1991). Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([³H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site. Journal of Labelled Compounds and Radiopharmaceuticals, 29(2), 125-129. https://doi.org/10.1002/jlcr.2580290202

@article{bd98d7984d664fb091623f20f68548ad,

title = "Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([3H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site",

abstract = "A tritiated photoaffinity ligand for the dopamine reuptake transporter protein, 1‐[2‐(diphenylmethoxy) ethyl]‐4‐[3‐(3‐azidophenyl)‐2,3‐ditritiopropyl]piperazine, of specific activity 41.8 Ci/mmol, was prepared in six steps starting from 1‐[2‐(diphenylmethoxy)ethyl] piperazine.",

keywords = "1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine, 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐phenylpropyl]piperazine, Cocaine, GBR‐12935, dopamine reuptake, tritium",

author = "A. Thurkauf and {de Costa}, B. and P. Berger and S. Paul and Rice, {K. C.}",

year = "1991",

month = feb,

doi = "10.1002/jlcr.2580290202",

language = "English",

volume = "29",

pages = "125--129",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

number = "2",

}

Thurkauf, A, de Costa, B, Berger, P, Paul, S & Rice, KC 1991, 'Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([³H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site', Journal of Labelled Compounds and Radiopharmaceuticals, vol. 29, no. 2, pp. 125-129. https://doi.org/10.1002/jlcr.2580290202

Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([³H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site. / Thurkauf, A.; de Costa, B.; Berger, P. et al.
In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 29, No. 2, 02.1991, p. 125-129.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([3H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site

AU - Thurkauf, A.

AU - de Costa, B.

AU - Berger, P.

AU - Paul, S.

AU - Rice, K. C.

PY - 1991/2

Y1 - 1991/2

N2 - A tritiated photoaffinity ligand for the dopamine reuptake transporter protein, 1‐[2‐(diphenylmethoxy) ethyl]‐4‐[3‐(3‐azidophenyl)‐2,3‐ditritiopropyl]piperazine, of specific activity 41.8 Ci/mmol, was prepared in six steps starting from 1‐[2‐(diphenylmethoxy)ethyl] piperazine.

AB - A tritiated photoaffinity ligand for the dopamine reuptake transporter protein, 1‐[2‐(diphenylmethoxy) ethyl]‐4‐[3‐(3‐azidophenyl)‐2,3‐ditritiopropyl]piperazine, of specific activity 41.8 Ci/mmol, was prepared in six steps starting from 1‐[2‐(diphenylmethoxy)ethyl] piperazine.

KW - 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine

KW - 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐phenylpropyl]piperazine

KW - Cocaine

KW - GBR‐12935

KW - dopamine reuptake

KW - tritium

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U2 - 10.1002/jlcr.2580290202

DO - 10.1002/jlcr.2580290202

M3 - Article

AN - SCOPUS:0026068904

SN - 0362-4803

VL - 29

SP - 125

EP - 129

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

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ER -

Synthesis of tritiated 1‐[2‐(diphenylmethoxy)ethyl]‐4‐[3‐(3‐azidophenyl)propyl]piperazine ([³H]‐meta azido GBR‐12935), a photoaffinity ligand for the dopamine reuptake site

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