Synthesis of the Selective D₂ Receptor Agonist PNU-95666E from D-Phenylalanine Using a Sequential Oxidative Cyclization Strategy

Keyphrases

• Phenylalanine 100%
• Synthetic Routes 100%
• Dopamine D2 Receptor Agonist 100%
• Oxidative Cyclization 100%
• High Efficiency 50%
• Parkinson's Disease 50%
• High Affinity 50%
• Receptor Subtypes 50%
• Racemization 50%
• Functional Groups 50%
• Dopamine D2 Receptor (DRD2) 50%
• Overall Yield 50%
• Enantiomerically Pure 50%
• Hydrides 50%
• Efficient Reduction 50%
• Annulation 50%
• Methyl Sulfide 50%
• Selective Affinity 50%
• Eight-step 50%
• Boranes 50%
• Tricyclic System 50%
• Tricyclic Compounds 50%

Chemistry

• D-Phenylalanine 100%
• Oxidative Cyclization 100%
• Agent Interacting With Transmitter, Hormone or Drug Receptor 100%
• Cyclic Structure 50%
• Purity 50%
• Ring Formation 50%
• Methyl Sulfide 50%
• Borane 50%