Synthesis of soft alkyl phenolic ether prodrugs using Mitsunobu chemistry

Susruta Majumdar; Juha Juntunen; Sashi Sivendran; Neelam Bharti; K. B. Sloan

doi:10.1016/j.tetlet.2006.09.162

Synthesis of soft alkyl phenolic ether prodrugs using Mitsunobu chemistry

Susruta Majumdar
, Juha Juntunen
, Sashi Sivendran
, Neelam Bharti
, K. B. Sloan

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The synthesis of soft alkyl phenolic ether prodrugs in excellent yields has been reported by coupling a phenol with a hydroxymethylimide using Mitsunobu chemistry. The imides used in this study include saccharin, phthalimide, succinimide and two other compounds containing acidic imide-like N-H groups, benzotriazole, and imidazole.

Original language	English
Pages (from-to)	8981-8982
Number of pages	2
Journal	Tetrahedron Letters
Volume	47
Issue number	50
DOIs	https://doi.org/10.1016/j.tetlet.2006.09.162
State	Published - Dec 11 2006

Keywords

Imide
Mitsunobu coupling
Phenolic ethers
Prodrugs

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10.1016/j.tetlet.2006.09.162

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title = "Synthesis of soft alkyl phenolic ether prodrugs using Mitsunobu chemistry",

abstract = "The synthesis of soft alkyl phenolic ether prodrugs in excellent yields has been reported by coupling a phenol with a hydroxymethylimide using Mitsunobu chemistry. The imides used in this study include saccharin, phthalimide, succinimide and two other compounds containing acidic imide-like N-H groups, benzotriazole, and imidazole.",

keywords = "Imide, Mitsunobu coupling, Phenolic ethers, Prodrugs",

author = "Susruta Majumdar and Juha Juntunen and Sashi Sivendran and Neelam Bharti and Sloan, \{K. B.\}",

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journal = "Tetrahedron Letters",

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T1 - Synthesis of soft alkyl phenolic ether prodrugs using Mitsunobu chemistry

AU - Majumdar, Susruta

AU - Juntunen, Juha

AU - Sivendran, Sashi

AU - Bharti, Neelam

AU - Sloan, K. B.

PY - 2006/12/11

Y1 - 2006/12/11

N2 - The synthesis of soft alkyl phenolic ether prodrugs in excellent yields has been reported by coupling a phenol with a hydroxymethylimide using Mitsunobu chemistry. The imides used in this study include saccharin, phthalimide, succinimide and two other compounds containing acidic imide-like N-H groups, benzotriazole, and imidazole.

AB - The synthesis of soft alkyl phenolic ether prodrugs in excellent yields has been reported by coupling a phenol with a hydroxymethylimide using Mitsunobu chemistry. The imides used in this study include saccharin, phthalimide, succinimide and two other compounds containing acidic imide-like N-H groups, benzotriazole, and imidazole.

KW - Imide

KW - Mitsunobu coupling

KW - Phenolic ethers

KW - Prodrugs

UR - https://www.scopus.com/pages/publications/33750613450

U2 - 10.1016/j.tetlet.2006.09.162

DO - 10.1016/j.tetlet.2006.09.162

M3 - Article

AN - SCOPUS:33750613450

SN - 0040-4039

VL - 47

SP - 8981

EP - 8982

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 50

ER -

Synthesis of soft alkyl phenolic ether prodrugs using Mitsunobu chemistry

Abstract

Keywords

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