Synthesis of non-peptide bradykinin B2 receptor antagonists

Brent D. Douty, Joseph M. Salvino, Peter R. Seoane, Roland E. Dolle

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The syntheses of the potent, competitive bradykinin B2 receptor antagonists, 1-3, are described. These compounds represent the three structural classes of B2 receptor antagonists discovered in our program. Compounds 1-3 bind to the human IMR 90 fetal lung fibroblast bradykinin B2 receptor with affinity constants Ki = 3.4 μM, 0.77 μM, and 0.060 μM, respectively.

Original languageEnglish
Pages (from-to)363-366
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Issue number4
StatePublished - Feb 16 1995


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