TY - JOUR
T1 - Synthesis of non-peptide bradykinin B2 receptor antagonists
AU - Douty, Brent D.
AU - Salvino, Joseph M.
AU - Seoane, Peter R.
AU - Dolle, Roland E.
PY - 1995/2/16
Y1 - 1995/2/16
N2 - The syntheses of the potent, competitive bradykinin B2 receptor antagonists, 1-3, are described. These compounds represent the three structural classes of B2 receptor antagonists discovered in our program. Compounds 1-3 bind to the human IMR 90 fetal lung fibroblast bradykinin B2 receptor with affinity constants Ki = 3.4 μM, 0.77 μM, and 0.060 μM, respectively.
AB - The syntheses of the potent, competitive bradykinin B2 receptor antagonists, 1-3, are described. These compounds represent the three structural classes of B2 receptor antagonists discovered in our program. Compounds 1-3 bind to the human IMR 90 fetal lung fibroblast bradykinin B2 receptor with affinity constants Ki = 3.4 μM, 0.77 μM, and 0.060 μM, respectively.
UR - http://www.scopus.com/inward/record.url?scp=0028812450&partnerID=8YFLogxK
U2 - 10.1016/0960-894X(95)00036-S
DO - 10.1016/0960-894X(95)00036-S
M3 - Article
AN - SCOPUS:0028812450
SN - 0960-894X
VL - 5
SP - 363
EP - 366
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
IS - 4
ER -