We present the rationale, synthesis and evaluation of the first activatable fluorescent probe that utilizes fluorescence lifetime change for detection of nitric oxide. The new probe DAP-LT1 features a near-infrared polymethine skeleton with a diaminobenzene functionality incorporated into the meso-position. The probe is partially quenched, and upon reaction with nitric oxide shows an increase in the fluorescence lifetime from 1.08 ns to 1.24 ns.

Original languageEnglish
Pages (from-to)8228-8234
Number of pages7
JournalOrganic and Biomolecular Chemistry
Issue number47
StatePublished - Dec 21 2013


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