Synthesis of nitric oxide probes with fluorescence lifetime sensitivity

Natalia G. Zhegalova; Garrett Gonzales; Mikhail Y. Berezin

doi:10.1039/c3ob41498a

Synthesis of nitric oxide probes with fluorescence lifetime sensitivity

Natalia G. Zhegalova, Garrett Gonzales, Mikhail Y. Berezin

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

We present the rationale, synthesis and evaluation of the first activatable fluorescent probe that utilizes fluorescence lifetime change for detection of nitric oxide. The new probe DAP-LT1 features a near-infrared polymethine skeleton with a diaminobenzene functionality incorporated into the meso-position. The probe is partially quenched, and upon reaction with nitric oxide shows an increase in the fluorescence lifetime from 1.08 ns to 1.24 ns.

Original language	English
Pages (from-to)	8228-8234
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	47
DOIs	https://doi.org/10.1039/c3ob41498a
State	Published - Dec 21 2013

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title = "Synthesis of nitric oxide probes with fluorescence lifetime sensitivity",

abstract = "We present the rationale, synthesis and evaluation of the first activatable fluorescent probe that utilizes fluorescence lifetime change for detection of nitric oxide. The new probe DAP-LT1 features a near-infrared polymethine skeleton with a diaminobenzene functionality incorporated into the meso-position. The probe is partially quenched, and upon reaction with nitric oxide shows an increase in the fluorescence lifetime from 1.08 ns to 1.24 ns.",

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AB - We present the rationale, synthesis and evaluation of the first activatable fluorescent probe that utilizes fluorescence lifetime change for detection of nitric oxide. The new probe DAP-LT1 features a near-infrared polymethine skeleton with a diaminobenzene functionality incorporated into the meso-position. The probe is partially quenched, and upon reaction with nitric oxide shows an increase in the fluorescence lifetime from 1.08 ns to 1.24 ns.

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JO - Organic and Biomolecular Chemistry

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Synthesis of nitric oxide probes with fluorescence lifetime sensitivity

Abstract

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