Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus

Dipanjan Pan; Shelton D. Caruthers; Angana Senpan; Ceren Yalaz; Allen J. Stacy; Grace Hu; Jon N. Marsh; Patrick J. Gaffney; Samuel A. Wickline; Gregory M. Lanza

doi:10.1021/ja201918u

Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus

Dipanjan Pan
, Shelton D. Caruthers
, Angana Senpan
, Ceren Yalaz
, Allen J. Stacy
, Grace Hu
, Jon N. Marsh
, Patrick J. Gaffney
, Samuel A. Wickline
, Gregory M. Lanza

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.

Original language	English
Pages (from-to)	9168-9171
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	133
Issue number	24
DOIs	https://doi.org/10.1021/ja201918u
State	Published - Jun 22 2011

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Pan, D., Caruthers, S. D., Senpan, A., Yalaz, C., Stacy, A. J., Hu, G., Marsh, J. N., Gaffney, P. J., Wickline, S. A., & Lanza, G. M. (2011). Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus. Journal of the American Chemical Society, 133(24), 9168-9171. https://doi.org/10.1021/ja201918u

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abstract = "A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.",

author = "Dipanjan Pan and Caruthers, \{Shelton D.\} and Angana Senpan and Ceren Yalaz and Stacy, \{Allen J.\} and Grace Hu and Marsh, \{Jon N.\} and Gaffney, \{Patrick J.\} and Wickline, \{Samuel A.\} and Lanza, \{Gregory M.\}",

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doi = "10.1021/ja201918u",

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AU - Pan, Dipanjan

AU - Caruthers, Shelton D.

AU - Senpan, Angana

AU - Yalaz, Ceren

AU - Stacy, Allen J.

AU - Hu, Grace

AU - Marsh, Jon N.

AU - Gaffney, Patrick J.

AU - Wickline, Samuel A.

AU - Lanza, Gregory M.

PY - 2011/6/22

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AB - A new site-targeted molecular imaging contrast agent based on a nanocolloidal suspension of lipid-encapsulated, organically soluble divalent copper has been developed. Concentrating a high payload of divalent copper ions per nanoparticle, this agent provides a high per-particle r1 relaxivity, allowing sensitive detection in T1-weighted magnetic resonance imaging when targeted to fibrin clots in vitro. The particle also exhibits a defined clearance and safety profile in vivo.

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IS - 24

ER -

Synthesis of NanoQ, a copper-based contrast agent for high-resolution magnetic resonance imaging characterization of human thrombus

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