Synthesis of myristic acid analogs with anti-HIV activity that may be resistant to metabolic processing by β-oxidation

Balekudru Devadas, Nandini S. Kishore, Steven P. Adams, Jeffrey I. Gordon

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Novel classes of oxatetradecanoic acid analogs 10, 11, 13, 16, and 21 were synthesized as alternative substrates for myristoylCoA:protein N-myristoyltransferase. These compounds inhibit replication of human immunodeficiency virus I (HIV-I) in acutely infected CD4-positive human T lymphocyte cell lines. The antiviral activity and potential metabolic stability of these compounds may make attractive therapeutic agents.

Original languageEnglish
Pages (from-to)779-784
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Volume3
Issue number4
DOIs
StatePublished - Apr 1993

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