Synthesis of myristic acid analogs with anti-HIV activity that may be resistant to metabolic processing by β-oxidation

Balekudru Devadas; Nandini S. Kishore; Steven P. Adams; Jeffrey I. Gordon

doi:10.1016/S0960-894X(01)81274-9

Synthesis of myristic acid analogs with anti-HIV activity that may be resistant to metabolic processing by β-oxidation

Balekudru Devadas, Nandini S. Kishore, Steven P. Adams, Jeffrey I. Gordon

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16 Scopus citations

Abstract

Novel classes of oxatetradecanoic acid analogs 10, 11, 13, 16, and 21 were synthesized as alternative substrates for myristoylCoA:protein N-myristoyltransferase. These compounds inhibit replication of human immunodeficiency virus I (HIV-I) in acutely infected CD4-positive human T lymphocyte cell lines. The antiviral activity and potential metabolic stability of these compounds may make attractive therapeutic agents.

Original language	English
Pages (from-to)	779-784
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/S0960-894X(01)81274-9
State	Published - Apr 1993

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title = "Synthesis of myristic acid analogs with anti-HIV activity that may be resistant to metabolic processing by β-oxidation",

abstract = "Novel classes of oxatetradecanoic acid analogs 10, 11, 13, 16, and 21 were synthesized as alternative substrates for myristoylCoA:protein N-myristoyltransferase. These compounds inhibit replication of human immunodeficiency virus I (HIV-I) in acutely infected CD4-positive human T lymphocyte cell lines. The antiviral activity and potential metabolic stability of these compounds may make attractive therapeutic agents.",

author = "Balekudru Devadas and Kishore, {Nandini S.} and Adams, {Steven P.} and Gordon, {Jeffrey I.}",

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AU - Devadas, Balekudru

AU - Kishore, Nandini S.

AU - Adams, Steven P.

AU - Gordon, Jeffrey I.

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N2 - Novel classes of oxatetradecanoic acid analogs 10, 11, 13, 16, and 21 were synthesized as alternative substrates for myristoylCoA:protein N-myristoyltransferase. These compounds inhibit replication of human immunodeficiency virus I (HIV-I) in acutely infected CD4-positive human T lymphocyte cell lines. The antiviral activity and potential metabolic stability of these compounds may make attractive therapeutic agents.

AB - Novel classes of oxatetradecanoic acid analogs 10, 11, 13, 16, and 21 were synthesized as alternative substrates for myristoylCoA:protein N-myristoyltransferase. These compounds inhibit replication of human immunodeficiency virus I (HIV-I) in acutely infected CD4-positive human T lymphocyte cell lines. The antiviral activity and potential metabolic stability of these compounds may make attractive therapeutic agents.

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DO - 10.1016/S0960-894X(01)81274-9

M3 - Article

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JO - Bioorganic and Medicinal Chemistry Letters

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ER -

Synthesis of myristic acid analogs with anti-HIV activity that may be resistant to metabolic processing by β-oxidation

Abstract

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