2-[18F]fluoroadenosine (2-[18F]FAD), a potential radioligand for assessment of adenylate metabolism, was synthesized by carrier-added and no-carrier-added procedures via nucleophilic radiofluorination of 2-fluoroadenosine and 2-iodoadenosine. The radiochemical yield, specific radioactivity and radiochemical purity of carrier-added and no-carrier-added 2-[18F]FAD were 5%, 22-30 mCi/μmol and 99%, and 0.5%, 1200-1700 mCi/μmol and 99%, respectively.
|Number of pages||5|
|Journal||Journal of Labelled Compounds and Radiopharmaceuticals|
|State||Published - Aug 1 2006|
- 2-[F] fluoroadenosine
- Adenylate metabolism
- Positron emission tomography