Synthesis, characterization, and antimalarial activity of novel Schiff-base-phenol and naphthalene-amine ligands

Scott E. Harpstrite, Silvia D. Collins, Ana Oksman, Daniel E. Goldberg, Vijay Sharma

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 μM against CQ-resistant Dd2 strains.

Original languageEnglish
Pages (from-to)392-395
Number of pages4
JournalMedicinal Chemistry
Volume4
Issue number4
DOIs
StatePublished - Aug 28 2008

Keywords

  • Antimalarials
  • Chloroquine-resistance
  • Naphthalene-amine
  • P. falciparum
  • Schiff-base phenol

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