Synthesis, characterization, and antimalarial activity of novel Schiff-base-phenol and naphthalene-amine ligands

Scott E. Harpstrite; Silvia D. Collins; Ana Oksman; Daniel E. Goldberg; Vijay Sharma

doi:10.2174/157340608784872280

Synthesis, characterization, and antimalarial activity of novel Schiff-base-phenol and naphthalene-amine ligands

Scott E. Harpstrite, Silvia D. Collins, Ana Oksman, Daniel E. Goldberg, Vijay Sharma

Research output: Contribution to journal › Article › peer-review

44 Scopus citations

Abstract

Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC₅₀) of 1.7 μM against CQ-resistant Dd2 strains.

Original language	English
Pages (from-to)	392-395
Number of pages	4
Journal	Medicinal Chemistry
Volume	4
Issue number	4
DOIs	https://doi.org/10.2174/157340608784872280
State	Published - 2008

Keywords

Antimalarials
Chloroquine-resistance
Naphthalene-amine
P. falciparum
Schiff-base phenol

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10.2174/157340608784872280

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title = "Synthesis, characterization, and antimalarial activity of novel Schiff-base-phenol and naphthalene-amine ligands",

abstract = "Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 μM against CQ-resistant Dd2 strains.",

keywords = "Antimalarials, Chloroquine-resistance, Naphthalene-amine, P. falciparum, Schiff-base phenol",

author = "Harpstrite, {Scott E.} and Collins, {Silvia D.} and Ana Oksman and Goldberg, {Daniel E.} and Vijay Sharma",

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T1 - Synthesis, characterization, and antimalarial activity of novel Schiff-base-phenol and naphthalene-amine ligands

AU - Harpstrite, Scott E.

AU - Collins, Silvia D.

AU - Oksman, Ana

AU - Goldberg, Daniel E.

AU - Sharma, Vijay

PY - 2008

Y1 - 2008

N2 - Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 μM against CQ-resistant Dd2 strains.

AB - Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC50) of 1.7 μM against CQ-resistant Dd2 strains.

KW - Antimalarials

KW - Chloroquine-resistance

KW - Naphthalene-amine

KW - P. falciparum

KW - Schiff-base phenol

UR - http://www.scopus.com/inward/record.url?scp=50049129392&partnerID=8YFLogxK

U2 - 10.2174/157340608784872280

DO - 10.2174/157340608784872280

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AN - SCOPUS:50049129392

SN - 1573-4064

VL - 4

SP - 392

EP - 395

JO - Medicinal Chemistry

JF - Medicinal Chemistry

IS - 4

ER -

Synthesis, characterization, and antimalarial activity of novel Schiff-base-phenol and naphthalene-amine ligands

Abstract

Keywords

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