Synthesis and evaluation of a bromine-76-labeled PPARγ antagonist 2-bromo-5-nitro-N-phenylbenzamide

Keyphrases

• Nitro 100%
• Peroxisome Proliferator-activated Receptor 100%
• Bromo 100%
• Bromine-76 100%
• N-phenylbenzamide 100%
• Benzamide 28%
• Chloro 28%
• GW9662 28%
• Tumor 14%
• Gene Expression 14%
• Fat Metabolism 14%
• Type 2 Diabetes Mellitus (T2DM) 14%
• Primary Tumor 14%
• Tumor Cell Lines 14%
• IC50 Value 14%
• Receptor Agonist 14%
• Prostate Tumor 14%
• Breast Tumor 14%
• Whole Blood 14%
• Downstream Genes 14%
• Radiotracer 14%
• Biodistribution Studies 14%
• Peroxisome 14%
• Binding Activity 14%
• Phenyl 14%
• Response Element 14%
• Parent Compounds 14%
• Pharmacological Properties 14%
• Stability Study 14%
• Retinoid X Receptor 14%
• Human Breast Tumor 14%
• MDA-MB-435 14%
• Radiotracer Development 14%
• Screening Assays 14%
• Bromine 14%
• In Vitro Stability 14%
• Tumor-bearing nude Mice 14%
• T0070907 14%
• Halogen-substituted 14%
• Metabolites Study 14%
• In Vivo Metabolites 14%
• Compound Degradation 14%
• Whole-cell Screening 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Bromine 76 100%
• Peroxisome Proliferator Activated Receptor Gamma 100%
• Peroxisome Proliferator Activated Receptor Gamma Antagonist 100%
• Neoplasm 40%
• Receptor 40%
• Breast Tumor 40%
• Tracer 40%
• Benzamide 40%
• Lead Compound 40%
• 2 Chloro 5 Nitrobenzanilide 40%
• Primary Tumor 20%
• Receptor Agonist 20%
• Prostate Tumor 20%
• Biodistribution 20%
• Nude Mouse 20%
• Retinoid X Receptor 20%
• 2 Chloro 5 Nitro N (4 Pyridyl)benzamide 20%
• EC50 20%
• Maturity Onset Diabetes of the Young 20%