Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides

Neelesh R. Soman, Gregory M. Lanza, John M. Heuser, Paul H. Schlesinger, Samuel A. Wickline

Research output: Contribution to journalArticle

98 Scopus citations

Abstract

The therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic degradation. We report the first stable incorporation of mellttin (a 26 amino acid amphipathic peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly to the nanoparticles (dissociation constant -3.27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.

Original languageEnglish
Pages (from-to)1131-1136
Number of pages6
JournalNano Letters
Volume8
Issue number4
DOIs
StatePublished - Apr 1 2008

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