Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides

Neelesh R. Soman; Gregory M. Lanza; John M. Heuser; Paul H. Schlesinger; Samuel A. Wickline

doi:10.1021/nl073290r

Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides

Neelesh R. Soman, Gregory M. Lanza, John M. Heuser, Paul H. Schlesinger, Samuel A. Wickline

Research output: Contribution to journal › Article › peer-review

118 Scopus citations

Abstract

The therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic degradation. We report the first stable incorporation of mellttin (a 26 amino acid amphipathic peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly to the nanoparticles (dissociation constant -3.27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.

Original language	English
Pages (from-to)	1131-1136
Number of pages	6
Journal	Nano Letters
Volume	8
Issue number	4
DOIs	https://doi.org/10.1021/nl073290r
State	Published - Apr 2008

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abstract = "The therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic degradation. We report the first stable incorporation of mellttin (a 26 amino acid amphipathic peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly to the nanoparticles (dissociation constant -3.27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.",

author = "Soman, {Neelesh R.} and Lanza, {Gregory M.} and Heuser, {John M.} and Schlesinger, {Paul H.} and Wickline, {Samuel A.}",

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AU - Soman, Neelesh R.

AU - Lanza, Gregory M.

AU - Heuser, John M.

AU - Schlesinger, Paul H.

AU - Wickline, Samuel A.

PY - 2008/4

Y1 - 2008/4

N2 - The therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic degradation. We report the first stable incorporation of mellttin (a 26 amino acid amphipathic peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly to the nanoparticles (dissociation constant -3.27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.

AB - The therapeutic potential of cytolytic peptides is plagued by nonspecificity and enzymatic degradation. We report the first stable incorporation of mellttin (a 26 amino acid amphipathic peptide) into an outer lipid monolayer of perfluorocarbon nanoparticles. Melittin binds avidly to the nanoparticles (dissociation constant -3.27 nM) and retains its pore-forming activity after contact-mediated delivery to model bilayer membrane (liposomes) thereby demonstrating the effectiveness of perfluorocarbon nanoparticles as unique nanocarriers for cytolytic peptides.

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U2 - 10.1021/nl073290r

DO - 10.1021/nl073290r

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JO - Nano Letters

JF - Nano Letters

IS - 4

ER -

Synthesis and characterization of stable fluorocarbon nanostructures as drug delivery vehicles for cytolytic peptides

Abstract

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