Synthesis and characterization of more potent analogues of hirudin fragment 1-47 containing non-natural amino acids

Keyphrases

• Thrombin 100%
• Hirudin 100%
• Unnatural Amino Acids 100%
• Potent Inhibitor 50%
• Tert 50%
• Side Chain 33%
• Natural Fragments 33%
• Naphthylalanine 33%
• Specific Inhibitor 16%
• Synthetic Analogues 16%
• Structural Features 16%
• Fold Increase 16%
• Peptide Synthesis 16%
• Selective Inhibitor 16%
• Synthetic Peptides 16%
• Chain Orientation 16%
• Anticoagulants 16%
• Inhibitory Potency 16%
• Natural Products 16%
• Hydrophobic Residues 16%
• Thrombin Inhibition 16%
• Coagulation Mechanism 16%
• Electronic Structure 16%
• Rapid Transition 16%
• Natural Species 16%
• Ser2 16%
• Solid-phase Synthesis 16%
• Disulfide Cross-linking 16%
• Shape-dependent 16%
• Oriented Structure 16%
• Binding Entropy 16%
• Packing Effect 16%

Biochemistry, Genetics and Molecular Biology

• Amino Acids 100%
• Hirudin 100%
• Thrombin 100%
• Enzyme 14%
• Disulfide 14%
• Peptide Synthesis 14%
• Biochemistry 14%
• Solid Phase Synthesis 14%
• Arginine 14%

Chemistry

• Amino Acid 100%
• Thrombin 100%
• Tert-Butylglycine 42%
• Peptide Synthesis 14%
• Disulfide 14%
• Electronic State 14%
• Anticoagulant 14%
• Procoagulant 14%
• Natural Product 14%
• Arginine 14%