Synthesis and characterization of a macrocyclic near-infrared optical scaffold

Yunpeng Ye, Wen Ping Li, Carolyn J. Anderson, Jeffery Kao, Gregory V. Nikiforovich, Samuel Achilefu

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Macrocyclization of a bioactive peptide with a bifunctional near-infrared fluorescent optical probe gives a compound that retained the receptor binding affinity of the peptide and the photophysical properties of the optical probe. The robust nature of the new compound provides a structural framework for optimizing the activity of bioactive molecules and for monitoring chemical or biological processes in vivo and in vitro by near-infrared optical methods.

Original languageEnglish
Pages (from-to)7766-7767
Number of pages2
JournalJournal of the American Chemical Society
Volume125
Issue number26
DOIs
StatePublished - Jul 2 2003

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