Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter; Steven Kramer; John J. Talley; Thomas Penning; Paul Collins; Matthew J. Graneto; Karen Seibert; Carol M. Koboldt; Jaime Masferrer; Ben Zweifel

doi:10.1016/S0960-894X(99)00157-2

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Jeffery S. Carter
, Steven Kramer
, John J. Talley
, Thomas Penning
, Paul Collins
, Matthew J. Graneto
, Karen Seibert
, Carol M. Koboldt
, Jaime Masferrer
, Ben Zweifel

Department of Anesthesiology

Research output: Contribution to journal › Article › peer-review

180 Scopus citations

Abstract

A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo.

Original language	English
Pages (from-to)	1171-1174
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	9
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(99)00157-2
State	Published - Apr 19 1999

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title = "Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors",

abstract = "A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo.",

author = "Carter, \{Jeffery S.\} and Steven Kramer and Talley, \{John J.\} and Thomas Penning and Paul Collins and Graneto, \{Matthew J.\} and Karen Seibert and Koboldt, \{Carol M.\} and Jaime Masferrer and Ben Zweifel",

year = "1999",

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doi = "10.1016/S0960-894X(99)00157-2",

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T1 - Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

AU - Carter, Jeffery S.

AU - Kramer, Steven

AU - Talley, John J.

AU - Penning, Thomas

AU - Collins, Paul

AU - Graneto, Matthew J.

AU - Seibert, Karen

AU - Koboldt, Carol M.

AU - Masferrer, Jaime

AU - Zweifel, Ben

PY - 1999/4/19

Y1 - 1999/4/19

N2 - A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo.

AB - A series of sulfonamide-substituted 4,5-diarylthiazoles was prepared via three synthetic routes as selective COX-2 inhibitors. Recently in the synthesis of selective COX-2 inhibitors we have discovered that the sulfonamide moiety is a suitable replacement for the methylsulfonyl moiety yielding compounds with activity both in vitro and in vivo.

UR - https://www.scopus.com/pages/publications/0033583501

U2 - 10.1016/S0960-894X(99)00157-2

DO - 10.1016/S0960-894X(99)00157-2

M3 - Article

C2 - 10328307

AN - SCOPUS:0033583501

SN - 0960-894X

VL - 9

SP - 1171

EP - 1174

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 8

ER -

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Abstract

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