Syntheses of 18F‐labeled reduced haloperidol and 11C‐labeled reduced 3‐N‐methylspiperone

Hayden T. Ravert; Robert F. Dannals; Alan A. Wilson; Dean F. Wong; Henry N. Wagner

doi:10.1002/jlcr.2580290312

Syntheses of ¹⁸F‐labeled reduced haloperidol and ¹¹C‐labeled reduced 3‐N‐methylspiperone

Hayden T. Ravert, Robert F. Dannals, Alan A. Wilson, Dean F. Wong, Henry N. Wagner

Precision Radiotheranostics Translation Center (PRTC)

Research output: Contribution to journal › Comment/debate

3 Scopus citations

Abstract

¹⁸F‐Labeled reduced haloperidol and ¹¹C‐labeled reduced 3‐N‐methylspiperone were synthesized in a convenient and quantitative one step reduction from ¹⁸F‐labeled haloperidol and ¹¹C‐labeled N‐methylspiperone, respectively. Both products were purified by semipreparative HPLC and were obtained at high specific activity and radiochemical purity.

Original language	English
Pages (from-to)	337-343
Number of pages	7
Journal	Journal of Labelled Compounds and Radiopharmaceuticals
Volume	29
Issue number	3
DOIs	https://doi.org/10.1002/jlcr.2580290312
State	Published - Mar 1991

Keywords

Reduced haloperidol
carbon‐11
fluorine‐18
positron emission tomography
reduced methyl‐spiperone

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10.1002/jlcr.2580290312

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title = "Syntheses of 18F‐labeled reduced haloperidol and 11C‐labeled reduced 3‐N‐methylspiperone",

abstract = "18F‐Labeled reduced haloperidol and 11C‐labeled reduced 3‐N‐methylspiperone were synthesized in a convenient and quantitative one step reduction from 18F‐labeled haloperidol and 11C‐labeled N‐methylspiperone, respectively. Both products were purified by semipreparative HPLC and were obtained at high specific activity and radiochemical purity.",

keywords = "Reduced haloperidol, carbon‐11, fluorine‐18, positron emission tomography, reduced methyl‐spiperone",

author = "Ravert, {Hayden T.} and Dannals, {Robert F.} and Wilson, {Alan A.} and Wong, {Dean F.} and Wagner, {Henry N.}",

year = "1991",

month = mar,

doi = "10.1002/jlcr.2580290312",

language = "English",

volume = "29",

pages = "337--343",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

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T1 - Syntheses of 18F‐labeled reduced haloperidol and 11C‐labeled reduced 3‐N‐methylspiperone

AU - Ravert, Hayden T.

AU - Dannals, Robert F.

AU - Wilson, Alan A.

AU - Wong, Dean F.

AU - Wagner, Henry N.

PY - 1991/3

Y1 - 1991/3

N2 - 18F‐Labeled reduced haloperidol and 11C‐labeled reduced 3‐N‐methylspiperone were synthesized in a convenient and quantitative one step reduction from 18F‐labeled haloperidol and 11C‐labeled N‐methylspiperone, respectively. Both products were purified by semipreparative HPLC and were obtained at high specific activity and radiochemical purity.

AB - 18F‐Labeled reduced haloperidol and 11C‐labeled reduced 3‐N‐methylspiperone were synthesized in a convenient and quantitative one step reduction from 18F‐labeled haloperidol and 11C‐labeled N‐methylspiperone, respectively. Both products were purified by semipreparative HPLC and were obtained at high specific activity and radiochemical purity.

KW - Reduced haloperidol

KW - carbon‐11

KW - fluorine‐18

KW - positron emission tomography

KW - reduced methyl‐spiperone

UR - http://www.scopus.com/inward/record.url?scp=0026059850&partnerID=8YFLogxK

U2 - 10.1002/jlcr.2580290312

DO - 10.1002/jlcr.2580290312

M3 - Comment/debate

AN - SCOPUS:0026059850

SN - 0362-4803

VL - 29

SP - 337

EP - 343

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

IS - 3

ER -

Syntheses of ¹⁸F‐labeled reduced haloperidol and ¹¹C‐labeled reduced 3‐N‐methylspiperone

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Keywords

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