Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

Yongcheol Cho, Valentina Di Liberto, Dan Carlin, Namiko Abe, Kathy H. Li, Alma L. Burlingame, Shenheng Guan, Izhak Michaelevski, Valeria Cavalli

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons.

Original languageEnglish
Pages (from-to)15820-15832
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number22
DOIs
StatePublished - May 30 2014

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