10 Scopus citations


High-relaxivity T1-weighted (T1w) MR molecular imaging nanoparticles typically present high surface gadolinium payloads that can elicit significant acute complement activation (CA). The objective of this research was to develop a high T1w contrast nanoparticle with improved safety. We report the development, optimization, and characterization of a gadolinium-manganese hybrid nanocolloid (MnOL-Gd NC; 138 ± 10 (Dav)/nm; PDI: 0.06; zeta: -27 ± 2mV). High r1 particulate relaxivity with minute additions of Gd-DOTA-lipid conjugate to the MnOL nanocolloid surface achieved an unexpected paramagnetic synergism. This hybrid MnOL-Gd NC provided optimal MR TSE signal intensity at 5nM/voxel and lower levels consistent with the level expression anticipated for sparse biomarkers, such as neovascular integrins. MnOL NC produced optimal MR TSE signal intensity at 10nM/voxel concentrations and above. Importantly, MnOL-Gd NC avoided acute CA in vitro and in vivo while retaining minimal transmetallation risk.

Original languageEnglish
Pages (from-to)601-609
Number of pages9
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Issue number3
StatePublished - 2015


  • Complement activation
  • Contrast media
  • Gadolinium
  • MRI
  • Manganese
  • Nanoparticle


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