Syndactyly, or webbed digits, is one of the most common congenital hand anomalies. While syndactyly most often occurs as an isolated condition, it may be associated with other upper extremity musculoskeletal anomalies, including cleft hand, ulnar longitudinal deficiency, symbrachydactyly, and synpolydactyly. Syndactyly may involve the skin only or may include the bone. Treatment with digit separation and web space reconstruction is designed to maximize function and appearance. There are a variety of described surgical techniques to accomplish these goals. Outcomes vary depending on the web space involved and type of syndactyly, among other factors.