Synchronous quadruple primary neoplasms: Glioblastoma, neuroendocrine tumor, schwannoma and sessile serrated adenoma in a patient with history of prostate cancer

Shane Grace, Razi Muzaffar, Jula Veerapong, Samer Alkaade, Nishant Poddar, Nancy Phillips, Miguel Guzman, Jacqueline Batanian, Carole Vogler, Jin Ping Lai

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9 Scopus citations

Abstract

Quadruple synchronous primary neoplasms are exceedingly rare with only one case reported in the English literature. We herein report a case of synchronous quadruple primary neoplasms in a 70-year-old Arabic male with a history of prostate cancer who presented to our hospital for work-up of a brain mass found at an outside hospital. Subsequent 18Fluorodeoxyglucose (FDG) positron emission tomography demonstrated a 5.9-cm temporoparietal mass and three additional lesions, each with increased maximum standardized uptake value (SUVmax). Histologic exami nation, immunohistochemistry and cytogenetic analyses of the lesional tissue revealed four primary neoplastic lesions: primary glioblastoma, inguinal schwannoma, well-differentiated neuroendocrine tumor of the terminal ileum and an appendiceal sessile serrated adenoma/polyp. This case is unique among previous reports as our patient presented with four primary neoplasms synchronously. To the best of our knowledge, this combination of synchronous multiple primary neoplasms has not been reported in the English literature.

Original languageEnglish
Pages (from-to)2121-2127
Number of pages7
JournalAnticancer research
Volume35
Issue number4
StatePublished - Apr 1 2015

Keywords

  • Glioblastoma
  • Glioblastoma multiforme
  • Multiple primary malignant neoplasms
  • Neuroendocrine tumor
  • Schwannoma
  • Sessile serrated adenoma/polyp
  • Synchronous

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    Grace, S., Muzaffar, R., Veerapong, J., Alkaade, S., Poddar, N., Phillips, N., Guzman, M., Batanian, J., Vogler, C., & Lai, J. P. (2015). Synchronous quadruple primary neoplasms: Glioblastoma, neuroendocrine tumor, schwannoma and sessile serrated adenoma in a patient with history of prostate cancer. Anticancer research, 35(4), 2121-2127.