Synaptosomes and Synaptic Vesicles

Marion I. Stunault; Ghazaleh Ashrafi

doi:10.1016/B978-0-12-821618-7.00215-7

Synaptosomes and Synaptic Vesicles

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Synaptosomes are pseudo-organelles formed during homogenization of brain tissue. They represent synapses where the plasma membrane of the presynaptic axon terminal has resealed. They contain functional mitochondria and synaptic vesicles and can undergo regulated release of synaptic vesicles in response to membrane depolarization. Synaptic vesicles are small membrane-enclosed structures that contain neurotransmitters. These vesicles are present in the axon terminal and fuse with the plasma membrane to release their contents in an activity-dependent manner.

Original language	English
Title of host publication	Encyclopedia of Cell Biology
Subtitle of host publication	Volume 1-6, Second Edition
Publisher	Elsevier
Pages	363-377
Number of pages	15
Volume	2
ISBN (Electronic)	9780128216248
DOIs	https://doi.org/10.1016/B978-0-12-821618-7.00215-7
State	Published - Jan 1 2022

Keywords

Axon terminal
Clathrin
Endocytosis
Exocytosis
Mass spectrometry
Neurotransmitter
SNAP-25
SNARE
Synapse
Synaptic vesicle
Synaptobrevin
Synaptosome and Syntaxin

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10.1016/B978-0-12-821618-7.00215-7

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abstract = "Synaptosomes are pseudo-organelles formed during homogenization of brain tissue. They represent synapses where the plasma membrane of the presynaptic axon terminal has resealed. They contain functional mitochondria and synaptic vesicles and can undergo regulated release of synaptic vesicles in response to membrane depolarization. Synaptic vesicles are small membrane-enclosed structures that contain neurotransmitters. These vesicles are present in the axon terminal and fuse with the plasma membrane to release their contents in an activity-dependent manner.",

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AU - Stunault, Marion I.

AU - Ashrafi, Ghazaleh

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KW - Axon terminal

KW - Clathrin

KW - Endocytosis

KW - Exocytosis

KW - Mass spectrometry

KW - Neurotransmitter

KW - SNAP-25

KW - SNARE

KW - Synapse

KW - Synaptic vesicle

KW - Synaptobrevin

KW - Synaptosome and Syntaxin

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DO - 10.1016/B978-0-12-821618-7.00215-7

M3 - Chapter

AN - SCOPUS:85158964698

VL - 2

SP - 363

EP - 377

BT - Encyclopedia of Cell Biology

PB - Elsevier

ER -

Synaptosomes and Synaptic Vesicles

Abstract

Keywords

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