Symptom dimensions in obsessive-compulsive disorder: Toward quantitative phenotypes

Robert Freedman; Sherry Leonard; Judith M. Gault; Jan Hopkins; C. Robert Cloninger; Charles A. Kaufmann; Ming T. Tsuang; Stephen V. Farone; Dolores Malaspina; Dragan M. Svrakic; Alan Sanders; Pablo Gejman

doi:10.1002/1096-8628(20010108)105:1<28::AID-AJMG1050>3.0.CO;2-8

Symptom dimensions in obsessive-compulsive disorder: Toward quantitative phenotypes

Robert Freedman
, Sherry Leonard
, Judith M. Gault
, Jan Hopkins
, C. Robert Cloninger
, Charles A. Kaufmann
, Ming T. Tsuang
, Stephen V. Farone
, Dolores Malaspina
, Dragan M. Svrakic
, Alan Sanders
, Pablo Gejman

Division of Adult Acute Clinical

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

The authors review evidence of symptom dimensions in obsessive-compulsive disorder (OCD) and their potential value as quantitative phenotypes in genetic studies of OCD and related conditions. Preliminary evidence supports the existence of four separate symptom dimensions. A small series of clinical and family genetic studies support the validity of one or more of these dimensions. However, critical data concerning the distribution of these dimensions in the general population are lacking, and the hereditability of these traits has yet to be established.

Original language	English
Pages (from-to)	28-30
Number of pages	3
Journal	American Journal of Medical Genetics - Neuropsychiatric Genetics
Volume	105
Issue number	1
DOIs	https://doi.org/10.1002/1096-8628(20010108)105:1<28::AID-AJMG1050>3.0.CO;2-8
State	Published - Jan 8 2001

Keywords

Obsessive-compulsive disorder
Quantitative traits

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10.1002/1096-8628(20010108)105:1<28::AID-AJMG1050>3.0.CO;2-8

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Freedman, R., Leonard, S., Gault, J. M., Hopkins, J., Robert Cloninger, C., Kaufmann, C. A., Tsuang, M. T., Farone, S. V., Malaspina, D., Svrakic, D. M., Sanders, A., & Gejman, P. (2001). Symptom dimensions in obsessive-compulsive disorder: Toward quantitative phenotypes. American Journal of Medical Genetics - Neuropsychiatric Genetics, 105(1), 28-30. https://doi.org/10.1002/1096-8628(20010108)105:1<28::AID-AJMG1050>3.0.CO;2-8

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abstract = "The authors review evidence of symptom dimensions in obsessive-compulsive disorder (OCD) and their potential value as quantitative phenotypes in genetic studies of OCD and related conditions. Preliminary evidence supports the existence of four separate symptom dimensions. A small series of clinical and family genetic studies support the validity of one or more of these dimensions. However, critical data concerning the distribution of these dimensions in the general population are lacking, and the hereditability of these traits has yet to be established.",

keywords = "Obsessive-compulsive disorder, Quantitative traits",

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doi = "10.1002/1096-8628(20010108)105:1<28::AID-AJMG1050>3.0.CO;2-8",

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Freedman, R, Leonard, S, Gault, JM, Hopkins, J, Robert Cloninger, C, Kaufmann, CA, Tsuang, MT, Farone, SV, Malaspina, D, Svrakic, DM, Sanders, A & Gejman, P 2001, 'Symptom dimensions in obsessive-compulsive disorder: Toward quantitative phenotypes', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 105, no. 1, pp. 28-30. https://doi.org/10.1002/1096-8628(20010108)105:1<28::AID-AJMG1050>3.0.CO;2-8

TY - JOUR

T1 - Symptom dimensions in obsessive-compulsive disorder

T2 - Toward quantitative phenotypes

AU - Freedman, Robert

AU - Leonard, Sherry

AU - Gault, Judith M.

AU - Hopkins, Jan

AU - Robert Cloninger, C.

AU - Kaufmann, Charles A.

AU - Tsuang, Ming T.

AU - Farone, Stephen V.

AU - Malaspina, Dolores

AU - Svrakic, Dragan M.

AU - Sanders, Alan

AU - Gejman, Pablo

PY - 2001/1/8

Y1 - 2001/1/8

N2 - The authors review evidence of symptom dimensions in obsessive-compulsive disorder (OCD) and their potential value as quantitative phenotypes in genetic studies of OCD and related conditions. Preliminary evidence supports the existence of four separate symptom dimensions. A small series of clinical and family genetic studies support the validity of one or more of these dimensions. However, critical data concerning the distribution of these dimensions in the general population are lacking, and the hereditability of these traits has yet to be established.

AB - The authors review evidence of symptom dimensions in obsessive-compulsive disorder (OCD) and their potential value as quantitative phenotypes in genetic studies of OCD and related conditions. Preliminary evidence supports the existence of four separate symptom dimensions. A small series of clinical and family genetic studies support the validity of one or more of these dimensions. However, critical data concerning the distribution of these dimensions in the general population are lacking, and the hereditability of these traits has yet to be established.

KW - Obsessive-compulsive disorder

KW - Quantitative traits

UR - https://www.scopus.com/pages/publications/0035825227

U2 - 10.1002/1096-8628(20010108)105:1<28::AID-AJMG1050>3.0.CO;2-8

DO - 10.1002/1096-8628(20010108)105:1<28::AID-AJMG1050>3.0.CO;2-8

M3 - Article

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AN - SCOPUS:0035825227

SN - 1552-4841

VL - 105

SP - 28

EP - 30

JO - American Journal of Medical Genetics - Neuropsychiatric Genetics

JF - American Journal of Medical Genetics - Neuropsychiatric Genetics

IS - 1

ER -

Symptom dimensions in obsessive-compulsive disorder: Toward quantitative phenotypes

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Keywords

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