Symptom dimensions in obsessive-compulsive disorder: Toward quantitative phenotypes

Robert Freedman, Sherry Leonard, Judith M. Gault, Jan Hopkins, C. Robert Cloninger, Charles A. Kaufmann, Ming T. Tsuang, Stephen V. Farone, Dolores Malaspina, Dragan M. Svrakic, Alan Sanders, Pablo Gejman

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

The authors review evidence of symptom dimensions in obsessive-compulsive disorder (OCD) and their potential value as quantitative phenotypes in genetic studies of OCD and related conditions. Preliminary evidence supports the existence of four separate symptom dimensions. A small series of clinical and family genetic studies support the validity of one or more of these dimensions. However, critical data concerning the distribution of these dimensions in the general population are lacking, and the hereditability of these traits has yet to be established.

Original languageEnglish
Pages (from-to)28-30
Number of pages3
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume105
Issue number1
DOIs
StatePublished - Jan 8 2001

Keywords

  • Obsessive-compulsive disorder
  • Quantitative traits

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