Symptom Based Clustering of Men in the LURN Observational Cohort Study

Gang Liu, Victor P. Andreev, Margaret E. Helmuth, Claire C. Yang, H. Henry Lai, Abigail R. Smith, Jonathan B. Wiseman, Robert M. Merion, Bradley A. Erickson, David Cella, James W. Griffith, John L. Gore, John O.L. Delancey, Ziya Kirkali

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Purpose:Conventional classification of patients with lower urinary tract symptoms into diagnostic categories based on a predefined symptom complex or predominant symptom appears inadequate. This is due to the frequent presentation of patients with multiple urinary symptoms which could not be perfectly categorized into traditional diagnostic groups. We used a novel clustering method to identify subtypes of male patients with lower urinary tract symptoms based on detailed multisymptom information.Materials and Methods:We analyzed baseline data on 503 care seeking men in the LURN (Symptoms of Lower Urinary Tract Dysfunction Research Network) Observational Cohort Study. Symptoms and symptom severity were assessed using the LUTS (Lower Urinary Tract Symptoms) Tool and the AUA SI (American Urological Association Symptom Index), which include a total of 52 questions. We used a resampling based consensus clustering algorithm to identify patient subtypes with distinct symptom signatures.Results:Four distinct symptom clusters were identified. The 166 patients in cluster M1 had predominant symptoms of frequency, nocturia, hesitancy, straining, weak stream, intermittency and incomplete bladder emptying suggestive of bladder outlet obstruction. The 93 patients in cluster M2 mainly endorsed post-micturition symptoms (eg post-void dribbling and post-void leakage) with some weak stream. The 114 patients in cluster M3 reported mostly urinary frequency without incontinence. The 130 patients in cluster M4 reported severe frequency, urgency and urgency incontinence. Most other urinary symptoms statistically differed between cluster pairs. Patient reported outcomes of bowel symptoms, mental health, sleep dysfunction, erectile function and urological pain significantly differed across the clusters.Conclusions:We identified 4 data derived clusters among men seeking care for lower urinary tract symptoms. The clusters differed from traditional diagnostic categories. Further subtype refinement will be done to incorporate clinical data and nonurinary patient reported outcomes.

Original languageEnglish
Pages (from-to)1230-1239
Number of pages10
JournalJournal of Urology
Issue number6
StatePublished - Dec 1 2019


  • cluster analysis
  • diagnosis
  • lower urinary tract symptoms
  • patient reported outcome measures
  • urinary bladder


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