Symmetric abnormalities in sulcal patterning in schizophrenia

John G. Csernansky, Sarah K. Gillespie, Donna L. Dierker, Alan Anticevic, Lei Wang, Deanna M. Barch, David C. Van Essen

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

To compare the morphology of the cerebral cortex and its characteristic pattern of gyri and sulci in individuals with and without schizophrenia, T1-weighted magnetic resonance scans were collected, along with clinical and cognitive information, from 33 individuals with schizophrenia and 30 healthy individuals group-matched for age, gender, race and parental socioeconomic status. Sulcal depth was measured across the entire cerebral cortex by reconstructing surfaces of cortical mid-thickness (layer 4) in each hemisphere and registering them to the human PALS cortical atlas. Group differences in sulcal depth were tested using methods for cluster size analysis and interhemispheric symmetry analysis. A significant group difference was found bilaterally in the parietal operculum, where the average sulcal depth was shallower in individuals with schizophrenia. In addition, group differences in sulcal depth showed significant bilateral symmetry across much of the occipital, parietal, and temporal cortices. In individuals with schizophrenia, sulcal depth in the left hemisphere was correlated with the severity of impaired performance on tests of working memory and executive function.

Original languageEnglish
Pages (from-to)440-446
Number of pages7
JournalNeuroImage
Volume43
Issue number3
DOIs
StatePublished - Nov 15 2008

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