SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer

Amrita M. Nargund; Hatice U. Osmanbeyoglu; Emily H. Cheng; James J. Hsieh

doi:10.1080/23723556.2017.1342747

SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer

Amrita M. Nargund, Hatice U. Osmanbeyoglu, Emily H. Cheng, James J. Hsieh

Research output: Contribution to journal › Comment/debate

15 Scopus citations

Abstract

Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

Original language	English
Article number	e1342747
Journal	Molecular and Cellular Oncology
Volume	4
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2017.1342747
State	Published - Jul 4 2017

Keywords

BAF180
Clear Cell Kidney Cancer Mouse Model
Genomic Biomarkers
MTOR
PBRM1
SWI/SNF Chromatin Remodeling Tumor Suppressor Gene
VHL

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10.1080/23723556.2017.1342747

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title = "SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer",

abstract = "Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.",

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AU - Nargund, Amrita M.

AU - Osmanbeyoglu, Hatice U.

AU - Cheng, Emily H.

AU - Hsieh, James J.

PY - 2017/7/4

Y1 - 2017/7/4

N2 - Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

AB - Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

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KW - Clear Cell Kidney Cancer Mouse Model

KW - Genomic Biomarkers

KW - MTOR

KW - PBRM1

KW - SWI/SNF Chromatin Remodeling Tumor Suppressor Gene

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M1 - e1342747

ER -

SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer

Abstract

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