SWI/SNF tumor suppressor gene PBRM1/BAF180 in human clear cell kidney cancer

Amrita M. Nargund, Hatice U. Osmanbeyoglu, Emily H. Cheng, James J. Hsieh

Research output: Contribution to journalComment/debate

11 Scopus citations

Abstract

Mutations within chromatin modulating protein complexes have dominated the novel cancer gene landscape. However, little is known about how individual aberrations contribute to cancer formation. A novel Pbrm1 kidney cancer mouse model examining the role of Pbrm1 provides much needed clue concerning how SWI/SNF complexes might function as tumor suppressors.

Original languageEnglish
Article numbere1342747
JournalMolecular and Cellular Oncology
Volume4
Issue number4
DOIs
StatePublished - Jul 4 2017

Keywords

  • BAF180
  • Clear Cell Kidney Cancer Mouse Model
  • Genomic Biomarkers
  • MTOR
  • PBRM1
  • SWI/SNF Chromatin Remodeling Tumor Suppressor Gene
  • VHL

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