SWAMNA: a comprehensive platform for analysis of nucleic acid modifications

Yixuan Xie, Francisca N. De Luna Vitorino, Ye Chen, Joanna K. Lempiäinen, Chenfeng Zhao, Robert T. Steinbock, Zongtao Lin, Xingyu Liu, Emily Zahn, Arabella L. Garcia, Matthew D. Weitzman, Benjamin A. Garcia

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The interest in MS-based analysis of modified nucleic acids is increasing due to the application of nucleic acids in therapeutics. However, there are few available integrated platforms for characterizing nucleic acid modifications. Herein, we report a general mass spectrometry-based SWATH platform to identify and quantify both RNA and DNA modifications, which we call SWATH analysis of modified nucleic acids (SWAMNA). SWAMNA incorporates the search engine, NuMo finder, enabling the analysis of modifications in native and permethylated form. SWAMNA will aid discoveries that provide new insights into nucleic acid modifications.

Original languageEnglish
Pages (from-to)12499-12502
Number of pages4
JournalChemical Communications
Volume59
Issue number83
DOIs
StatePublished - Oct 3 2023

Fingerprint

Dive into the research topics of 'SWAMNA: a comprehensive platform for analysis of nucleic acid modifications'. Together they form a unique fingerprint.

Cite this