TY - JOUR
T1 - SWAMNA
T2 - a comprehensive platform for analysis of nucleic acid modifications
AU - Xie, Yixuan
AU - De Luna Vitorino, Francisca N.
AU - Chen, Ye
AU - Lempiäinen, Joanna K.
AU - Zhao, Chenfeng
AU - Steinbock, Robert T.
AU - Lin, Zongtao
AU - Liu, Xingyu
AU - Zahn, Emily
AU - Garcia, Arabella L.
AU - Weitzman, Matthew D.
AU - Garcia, Benjamin A.
N1 - Publisher Copyright:
© 2023 The Royal Society of Chemistry.
PY - 2023/10/3
Y1 - 2023/10/3
N2 - The interest in MS-based analysis of modified nucleic acids is increasing due to the application of nucleic acids in therapeutics. However, there are few available integrated platforms for characterizing nucleic acid modifications. Herein, we report a general mass spectrometry-based SWATH platform to identify and quantify both RNA and DNA modifications, which we call SWATH analysis of modified nucleic acids (SWAMNA). SWAMNA incorporates the search engine, NuMo finder, enabling the analysis of modifications in native and permethylated form. SWAMNA will aid discoveries that provide new insights into nucleic acid modifications.
AB - The interest in MS-based analysis of modified nucleic acids is increasing due to the application of nucleic acids in therapeutics. However, there are few available integrated platforms for characterizing nucleic acid modifications. Herein, we report a general mass spectrometry-based SWATH platform to identify and quantify both RNA and DNA modifications, which we call SWATH analysis of modified nucleic acids (SWAMNA). SWAMNA incorporates the search engine, NuMo finder, enabling the analysis of modifications in native and permethylated form. SWAMNA will aid discoveries that provide new insights into nucleic acid modifications.
UR - http://www.scopus.com/inward/record.url?scp=85174750477&partnerID=8YFLogxK
U2 - 10.1039/d3cc04402e
DO - 10.1039/d3cc04402e
M3 - Article
C2 - 37786919
AN - SCOPUS:85174750477
SN - 1359-7345
VL - 59
SP - 12499
EP - 12502
JO - Chemical Communications
JF - Chemical Communications
IS - 83
ER -