Sustained-released platelet-rich plasma from polyethylene glycol hydrogels exerts beneficial effects on chondrocytes

A. Blanco, E. Jain, N. Chinzei, N. Case, S. A. Sell, M. F. Rai, S. P. Zustiak

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Osteoarthritis (OA), a disease caused by chronic inflammation and wearing of articular cartilage, affects more than 50 million Americans. Currently available clinical treatments for this disease fail to suppress cartilage degeneration or synovial inflammation, or to promote tissue regeneration. Platelet-rich plasma (PRP) therapy involves a direct injection of PRP into the joint cavity. PRP is obtained by drawing patients own blood and concentrating platelets, which release bioactive factors that are critical to tissue regeneration and cellular recruitment. However, current strategies utilizing bolus injections of PRP remain ineffective due to a rapid clearance of growth factors. A sustained-release injectable formulation of PRP would be beneficial by maintaining a steady amount of the bioactive factors at the site of injury. Thus, in this study, we test therapeutic effects of sustained-released PRP, encapsulated as lyophilized powder (PRGF), from polyethylene glycol (PEG) hydrogels in vitro on human chondrocytes and tissue explants.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period04/3/1904/6/19

Fingerprint Dive into the research topics of 'Sustained-released platelet-rich plasma from polyethylene glycol hydrogels exerts beneficial effects on chondrocytes'. Together they form a unique fingerprint.

  • Cite this

    Blanco, A., Jain, E., Chinzei, N., Case, N., Sell, S. A., Rai, M. F., & Zustiak, S. P. (2019). Sustained-released platelet-rich plasma from polyethylene glycol hydrogels exerts beneficial effects on chondrocytes. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.