Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B

Ermanno Ciccone; Marco Colonna; Oriane Viale; Daniela Pende; Carolina Di Donato; Daniel Reinharz; Antonio Amoroso; Michel Jeannet; John Guardiola; Alessandro Moretta; Thomas Spies; Jack Strominger; Lorenzo Moretta

doi:10.1073/pnas.87.24.9794

Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B

Ermanno Ciccone, Marco Colonna, Oriane Viale, Daniela Pende, Carolina Di Donato, Daniel Reinharz, Antonio Amoroso, Michel Jeannet, John Guardiola, Alessandro Moretta, Thomas Spies, Jack Strominger, Lorenzo Moretta

Research output: Contribution to journal › Article › peer-review

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Abstract

The specificity recognized on normal allogeneic cells by a given alloreactive (1-anti-A) natural killer clone is controlled by a gene locus termed EC1. Because the EC1 locus was previously shown to be located on chromosome 6, families characterized by a recombinant major histocompatibility complex haplotype were analyzed to map this locus more precisely. The breakpoint of recombination was studied by standard HLA typing, complement typing, and restriction fragment length polymorphism analysis of a series of genes located between the complement cluster genes and HLA-B within the major histocompatibility complex region. Three of 10 families analyzed were informative. From the data obtained, the EC1 locus maps between BF and HLA-B and presumably is one of the normal genes recently described in this region.

Original language	English
Pages (from-to)	9794-9797
Number of pages	4
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	87
Issue number	24
DOIs	https://doi.org/10.1073/pnas.87.24.9794
State	Published - 1990

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10.1073/pnas.87.24.9794

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Ciccone, E., Colonna, M., Viale, O., Pende, D., Di Donato, C., Reinharz, D., Amoroso, A., Jeannet, M., Guardiola, J., Moretta, A., Spies, T., Strominger, J., & Moretta, L. (1990). Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B. Proceedings of the National Academy of Sciences of the United States of America, 87(24), 9794-9797. https://doi.org/10.1073/pnas.87.24.9794

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title = "Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B",

abstract = "The specificity recognized on normal allogeneic cells by a given alloreactive (1-anti-A) natural killer clone is controlled by a gene locus termed EC1. Because the EC1 locus was previously shown to be located on chromosome 6, families characterized by a recombinant major histocompatibility complex haplotype were analyzed to map this locus more precisely. The breakpoint of recombination was studied by standard HLA typing, complement typing, and restriction fragment length polymorphism analysis of a series of genes located between the complement cluster genes and HLA-B within the major histocompatibility complex region. Three of 10 families analyzed were informative. From the data obtained, the EC1 locus maps between BF and HLA-B and presumably is one of the normal genes recently described in this region.",

author = "Ermanno Ciccone and Marco Colonna and Oriane Viale and Daniela Pende and {Di Donato}, Carolina and Daniel Reinharz and Antonio Amoroso and Michel Jeannet and John Guardiola and Alessandro Moretta and Thomas Spies and Jack Strominger and Lorenzo Moretta",

year = "1990",

doi = "10.1073/pnas.87.24.9794",

language = "English",

volume = "87",

pages = "9794--9797",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

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Ciccone, E, Colonna, M, Viale, O, Pende, D, Di Donato, C, Reinharz, D, Amoroso, A, Jeannet, M, Guardiola, J, Moretta, A, Spies, T, Strominger, J & Moretta, L 1990, 'Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B', Proceedings of the National Academy of Sciences of the United States of America, vol. 87, no. 24, pp. 9794-9797. https://doi.org/10.1073/pnas.87.24.9794

Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B. / Ciccone, Ermanno; Colonna, Marco; Viale, Oriane et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 87, No. 24, 1990, p. 9794-9797.

Research output: Contribution to journal › Article › peer-review

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T1 - Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B

AU - Ciccone, Ermanno

AU - Colonna, Marco

AU - Viale, Oriane

AU - Pende, Daniela

AU - Di Donato, Carolina

AU - Reinharz, Daniel

AU - Amoroso, Antonio

AU - Jeannet, Michel

AU - Guardiola, John

AU - Moretta, Alessandro

AU - Spies, Thomas

AU - Strominger, Jack

AU - Moretta, Lorenzo

PY - 1990

Y1 - 1990

N2 - The specificity recognized on normal allogeneic cells by a given alloreactive (1-anti-A) natural killer clone is controlled by a gene locus termed EC1. Because the EC1 locus was previously shown to be located on chromosome 6, families characterized by a recombinant major histocompatibility complex haplotype were analyzed to map this locus more precisely. The breakpoint of recombination was studied by standard HLA typing, complement typing, and restriction fragment length polymorphism analysis of a series of genes located between the complement cluster genes and HLA-B within the major histocompatibility complex region. Three of 10 families analyzed were informative. From the data obtained, the EC1 locus maps between BF and HLA-B and presumably is one of the normal genes recently described in this region.

AB - The specificity recognized on normal allogeneic cells by a given alloreactive (1-anti-A) natural killer clone is controlled by a gene locus termed EC1. Because the EC1 locus was previously shown to be located on chromosome 6, families characterized by a recombinant major histocompatibility complex haplotype were analyzed to map this locus more precisely. The breakpoint of recombination was studied by standard HLA typing, complement typing, and restriction fragment length polymorphism analysis of a series of genes located between the complement cluster genes and HLA-B within the major histocompatibility complex region. Three of 10 families analyzed were informative. From the data obtained, the EC1 locus maps between BF and HLA-B and presumably is one of the normal genes recently described in this region.

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Susceptibility or resistance to lysis by alloreactive natural killer cells is governed by a gene in the human major histocompatibility complex between BF and HLA-B

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