Susceptibility of skeletal muscle to Coxsackie A2 virus infection: Effects of botulinum toxin and denervation

Clifford G. Andrew; Daniel B. Drachman; Alan Pestronk; Opendra Narayan

doi:10.1126/science.6320369

Susceptibility of skeletal muscle to Coxsackie A₂ virus infection: Effects of botulinum toxin and denervation

Clifford G. Andrew, Daniel B. Drachman, Alan Pestronk, Opendra Narayan

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Coxsackie A viruses can infect denervated but not innervated mature skeletal muscles. The role of synaptic transmission in preventing susceptibility to Coxsackievirus infection was studied by surgically denervating leg muscles of mice or injecting the muscles with botulinum toxin to block quantal release of acetylcholine. Control muscles were injected with heat-inactivated toxin. Subsequent injection of Coxsackie A₂ virus resulted in extensive virus replication and tissue destruction in the denervated and botulinum toxin-treated muscles, while the control muscles showed only minimal changes. This suggests that the susceptibility of skeletal muscle to Coxsackievirus infection is regulated by synoptic transmission.

Original language	English
Pages (from-to)	714-716
Number of pages	3
Journal	Science
Volume	223
Issue number	4637
DOIs	https://doi.org/10.1126/science.6320369
State	Published - 1984

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abstract = "Coxsackie A viruses can infect denervated but not innervated mature skeletal muscles. The role of synaptic transmission in preventing susceptibility to Coxsackievirus infection was studied by surgically denervating leg muscles of mice or injecting the muscles with botulinum toxin to block quantal release of acetylcholine. Control muscles were injected with heat-inactivated toxin. Subsequent injection of Coxsackie A2 virus resulted in extensive virus replication and tissue destruction in the denervated and botulinum toxin-treated muscles, while the control muscles showed only minimal changes. This suggests that the susceptibility of skeletal muscle to Coxsackievirus infection is regulated by synoptic transmission.",

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T2 - Effects of botulinum toxin and denervation

AU - Andrew, Clifford G.

AU - Drachman, Daniel B.

AU - Pestronk, Alan

AU - Narayan, Opendra

PY - 1984

Y1 - 1984

N2 - Coxsackie A viruses can infect denervated but not innervated mature skeletal muscles. The role of synaptic transmission in preventing susceptibility to Coxsackievirus infection was studied by surgically denervating leg muscles of mice or injecting the muscles with botulinum toxin to block quantal release of acetylcholine. Control muscles were injected with heat-inactivated toxin. Subsequent injection of Coxsackie A2 virus resulted in extensive virus replication and tissue destruction in the denervated and botulinum toxin-treated muscles, while the control muscles showed only minimal changes. This suggests that the susceptibility of skeletal muscle to Coxsackievirus infection is regulated by synoptic transmission.

AB - Coxsackie A viruses can infect denervated but not innervated mature skeletal muscles. The role of synaptic transmission in preventing susceptibility to Coxsackievirus infection was studied by surgically denervating leg muscles of mice or injecting the muscles with botulinum toxin to block quantal release of acetylcholine. Control muscles were injected with heat-inactivated toxin. Subsequent injection of Coxsackie A2 virus resulted in extensive virus replication and tissue destruction in the denervated and botulinum toxin-treated muscles, while the control muscles showed only minimal changes. This suggests that the susceptibility of skeletal muscle to Coxsackievirus infection is regulated by synoptic transmission.

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JO - Science

JF - Science

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ER -

Susceptibility of skeletal muscle to Coxsackie A₂ virus infection: Effects of botulinum toxin and denervation

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